Modern drug discovery is primarily based on the search and subsequent testing of drug
candidates acting on a preselected therapeutic target. Progress in genomics, protein …

Drugs exert their therapeutic effect by binding and regulating the activity of a particular
protein or nucleic acid target. A large number of targets have been explored for drug …

The advent of functional genomics, proteomics, chemi-informatics, and other systems-based
scientific approaches have raised expectations of novel targets for drug discovery and …

Low target discovery rate has been linked to inadequate consideration of multiple factors
that collectively contribute to druggability. These factors include sequence, structural …

Abstract Knowledge and investigation of therapeutic targets (responsible for drug efficacy)
and the targeted drugs facilitate target and drug discovery and validation. Therapeutic …

The recent publication of the human genome sequence provides an opportunity both to
combat diseases that are presently considered as pharmaceutically intractable and also to …

The past 30 years have witnessed a steady decline in the number of new drug targets. This
review concentrates on the initial process of target identification and argues that current …

The cataloguing of the human genome has provided an unprecedented prospectus for
target identification and drug discovery. A current analysis indicates that slightly more than …

A number of proteins and nucleic acids have been explored as therapeutic targets. These
targets are subjects of interest in different areas of biomedical and pharmaceutical research …

Genomics and proteomics technologies have created a paradigm shift in the drug discovery
process, with bioinformatics having a key role in the exploitation of genomic, transcriptomic …