We recently reported lower glycolytic flux (ATPGLY) and increased reliance on oxidative
ATP synthesis (ATPOX) in contracting muscle of older compared to young humans. To …

Skeletal muscle mass is in a constant state of turnover, and atrophy is the result of a shift in
the balance of muscle protein synthesis and breakdown resulting in net muscle protein loss …

Ageing is accompanied by decrements in the size and function of skeletal muscle that
compromise independence and quality of life in older adults. Developing therapeutic …

With advancing age, skeletal muscle function declines as a result of strength loss. These
strength deficits are largely due to reductions in muscle size (ie, quantity) and its intrinsic …

Skeletal muscle is a highly plastic tissue that remarkably adapts to diverse stimuli including
exercise, injury, disuse, and, as discussed here, aging. Humans achieve peak skeletal …

In old compared with young animals, muscle mass is decreased by 30% to 40%, and
maximum force and power are decreased to an even greater extent. The age-related …

Data are scarce relating to the plasticity with strength training of dynamic muscle
performance in older humans. Hence, we investigated alterations in the torque–velocity …

Abstract Changes in the neuromuscular system affecting the ageing motor unit manifest
structurally as a reduction in motor unit number secondary to motor neuron loss; fibre type …

Fatigue is a major limitation to the clinical application of functional electrical stimulation. The
activation pattern used during electrical stimulation affects force and fatigue. Identifying the …

During ageing, muscle loses much of its power-generating capacity. This is attributable to
both a decrease in force-generating capacity and a reduction in the shortening velocity. The …