Cancer genome sequencing studies indicate that a single breast cancer typically harbours
multiple genetically distinct subclones,,,. As carcinogenesis involves a breakdown in the cell …

The heterogeneity of cellular states in cancer has been linked to drug resistance, cancer
progression and the presence of cancer cells with properties of normal tissue stem cells …

Human cancers, including breast cancers, comprise clones differing in mutation content.
Clones evolve dynamically in space and time following principles of Darwinian evolution …

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many
tissues, activation of Wnt signalling has also been associated with cancer. This has raised …

Cancers arise through a process of somatic evolution that can result in substantial sub-
clonal heterogeneity within tumours. The mechanisms responsible for the coexistence of …

Recent studies have documented frequent evolution of clones carrying common cancer
mutations in apparently normal tissues, which are implicated in cancer development …

Genome sequencing of cancers often reveals mosaics of different subclones present in the
same tumour,–. Although these are believed to arise according to the principles of somatic …

Oncogenic mutations are abundant in the tissues of healthy individuals, but rarely form
tumours,–. Yet, the underlying protection mechanisms are largely unknown. To resolve …

Our knowledge of copy number evolution during the expansion of primary breast tumours is
limited,. Here, to investigate this process, we developed a single-cell, single-molecule DNA …

Cancer-associated systemic inflammation is strongly linked to poor disease outcome in
patients with cancer,. For most human epithelial tumour types, high systemic neutrophil-to …