We investigated the functions of Akt during vascular development and remodeling by using
an inducible endothelial cell-specific driver of the dominant-active myrAkt. We found that …

Vascular enlargement is a characteristic feature of angiopoietin-1 (Ang1)-induced changes
in adult blood vessels. However, it is unknown whether tissues having Ang1-mediated …

Protein kinase B (Akt1) holds a central role for cellular growth, development, and survival,
but the cellular pathways of Akt1 that prevent inflammatory demise in the vascular system …

Vascular permeability regulated by the vascular endothelial growth factor (VEGF) through
endothelial-barrier junctions is essential for inflammation. Mechanisms regulating vascular …

Endothelial dysfunction is associated with diverse cardiovascular pathologies. Here, we
show a previously unappreciated role for the Abelson (Abl) family kinases (Abl and Arg) in …

Arterial morphogenesis is an important and poorly understood process. In particular, the
signaling events controlling arterial formation have not been established. We evaluated …

Retinal angiogenesis was delayed in VSMC-specific Akt1-deficient mice (Akt1∆ SMC) but
not in Akt2∆ SMC mice. The proliferation of ECs, recruitment of pericytes, and coverage of …

Akt is a serine/threonine protein kinase that is activated by a number of growth factors and
cytokines in a phosphatidylinositol-3 kinase–dependent manner. Although antiapoptotic …

Vascular endothelial growth factor (VEGF) utilizes a phosphoinositide 3-kinase (PI 3-
kinase)/Akt signaling pathway to protect endothelial cells from apoptotic death. Here we …

Objective—Deletion of Akt1 leads to severe atherosclerosis and occlusive coronary artery
disease. Vascular smooth muscle cells (VSMCs) are an important component of …