Apoptosis of vascular smooth muscle cells (VSMCs) may lead to atherosclerotic plaque
instability and rupture, resulting in myocardial infarction, stroke, and sudden death …

Objective—Atherosclerosis is a focal disease that occurs predominantly at branches and
bends of the arterial tree. Endothelial cells (EC) at atherosusceptible sites are prone to …

The formation of endothelial lumen is fundamental to angiogenesis and essential to the
oxygenation of hypoxic tissues. The molecular mechanism underlying this important process …

Vascular ageing is accelerated in patients with diabetes. However, the underlying
mechanism remains unclear. Here, we show that high glucose induces activation of …

Rationale: Coronary artery disease, the direct result of atherosclerosis, is the most common
cause of death in Western societies. Vascular smooth muscle cell (VSMC) apoptosis occurs …

Rationale: Aortic aneurysm and dissection (AAD) are major diseases of the adult aorta
caused by progressive medial degeneration of the aortic wall. Although the overproduction …

Integrity of the blood vessel wall is essential for vascular homeostasis and organ function,. A
dynamic balance between endothelial cell survival and apoptosis contributes to this integrity …

The function of the endothelium is to provide a network to allow delivery of oxygen and
nutrients to tissues throughout the body. This network comprises adjacent endothelial cells …

Angiogenesis is a multistep process that requires coordinated migration, proliferation, and
junction formation of vascular endothelial cells (ECs) to form new vessel branches in …

BACKGROUND: In developmental and pathological tissues, nascent vessel networks
generated by angiogenesis require further pruning/regression to delete nonfunctional …