Molecular mechanisms controlling arterial–venous specification have not been fully
elucidated. Previously, we established an embryonic stem cell differentiation system and …

The formation of the vascular network requires a tightly controlled balance of pro-angiogenic
and stabilizing signals. Perturbation of this balance can result in dysregulated blood vessel …

BACKGROUND: In developmental and pathological tissues, nascent vessel networks
generated by angiogenesis require further pruning/regression to delete nonfunctional …

Endothelial to mesenchymal transition (EndMT), where endothelial cells acquire
mesenchymal characteristics has been implicated in several cardiopulmonary, vascular and …

Lysophosphatidic acid (LPA) is a potent lipid mediator with various biological functions
mediated through six G protein–coupled receptors (GPCRs), LPA1–LPA6. Previous studies …

Background and Aims Activation of the cAMP/Epac signalling stabilises endothelial barrier
function. Moreover, its activation is accompanied by an activation of PI3K/Akt and MEK/ERK …

Maintenance of vascular integrity in the adult animal is needed for survival, and it is critically
dependent on the endothelial lining, which controls barrier function, blood fluidity, and flow …

The vertebrate vasculature forms an extensive branched network of blood vessels that
supplies tissues with nutrients and oxygen. During vascular development, coordinated …

Pericyte-endothelial cell (EC) interactions are critical to both vascular development and
vessel stability. We have previously shown that TGF-β signaling between EC and mural cells …

Local flow patterns determine the uneven distribution of atherosclerotic lesions. This
research aims to elucidate the mechanism of regulation of nuclear translocation of Yes …