Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …

Abstract Development of malignancy is accompanied by a complete metabolic
reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key …

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Prostate cancer is no longer viewed mostly as a disease of abnormally proliferating
epithelial cells, but rather as a disease affecting the complex interactions between the cells …

Adaptation of cellular function with the nutrient environment is essential for survival. Failure
to adapt can lead to cell death and/or disease. Indeed, energy metabolism alterations are a …

Tumor metabolism is reorganized to support proliferation in the face of growth-related stress.
Unlike the widespread profiling of changes to metabolic enzyme levels in cancer …

Cancer is a complex disease of multiple alterations occuring at the epigenomic, genomic,
transcriptomic, proteomic and/or metabolic levels. The contribution of genetic mutations in …

Cancer cells must adapt their metabolism to meet the energetic and biosynthetic demands
that accompany rapid growth of the primary tumor and colonization of distinct metastatic …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …