[HTML][HTML] LANCL1 binds abscisic acid and stimulates glucose transport and mitochondrial respiration in muscle cells via the AMPK/PGC-1α/Sirt1 pathway

S Spinelli, G Begani, L Guida, M Magnone… - Molecular …, 2021 - Elsevier
Objective Abscisic acid (ABA) is a plant hormone also present and active in animals. In
mammals, ABA regulates blood glucose levels by stimulating insulin-independent glucose …

[HTML][HTML] G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2

C Fresia, T Vigliarolo, L Guida, V Booz, S Bruzzone… - Scientific reports, 2016 - nature.com
Abscisic acid (ABA), a long known phytohormone, has been recently demonstrated to be
present also in humans, where it targets cells of the innate immune response, mesenchymal …

Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo

L Sturla, E Mannino, S Scarfì, S Bruzzone… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Abscisic acid (ABA) is a plant hormone also present in animals, where it is involved in the
regulation of innate immune cell function and of glucose disposal, through its receptor …

[HTML][HTML] LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells

L Sturla, C Fresia, L Guida, S Bruzzone, S Scarfì… - Journal of Biological …, 2009 - ASBMB
Abscisic acid (ABA) is a plant hormone regulating fundamental physiological functions in
plants, such as response to abiotic stress. Recently, ABA was shown to be produced and …

[HTML][HTML] Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation

M Magnone, L Emionite, L Guida, T Vigliarolo… - Scientific reports, 2020 - nature.com
Abscisic acid (ABA) is a plant hormone active also in mammals where it regulates, at
nanomolar concentrations, blood glucose homeostasis. Here we investigated the …

Binding of abscisic acid to human LANCL2

L Sturla, C Fresia, L Guida, A Grozio, T Vigliarolo… - Biochemical and …, 2011 - Elsevier
The phytohormone abscisic acid (ABA) is the central regulator of abiotic stress in plants and
plays important roles during plant growth and development. In animal cells, ABA was shown …

Identification of a high affinity binding site for abscisic acid on human lanthionine synthetase component C-like protein 2

E Cichero, C Fresia, L Guida, V Booz, E Millo… - The international journal …, 2018 - Elsevier
Lanthionine synthetase component C-like protein 2 (LANCL2) has been identified as the
mammalian receptor mediating the functional effects of the universal stress hormone …

[HTML][HTML] The ABA/LANCL1/2 Hormone/Receptor System Controls Adipocyte Browning and Energy Expenditure

S Spinelli, V Cossu, M Passalacqua… - International Journal of …, 2023 - mdpi.com
The abscisic acid (ABA)/LANC-like protein 1/2 (LANCL1/2) hormone/receptor system
regulates glucose uptake and oxidation, mitochondrial respiration, and proton gradient …

[HTML][HTML] Abscisic acid transport in human erythrocytes

T Vigliarolo, L Guida, E Millo, C Fresia, E Turco… - Journal of Biological …, 2015 - ASBMB
Abscisic acid (ABA) is a plant hormone involved in the response to environmental stress.
Recently, ABA has been shown to be present and active also in mammals, where it …

[HTML][HTML] Abscisic acid: A conserved hormone in plants and humans and a promising aid to combat prediabetes and the metabolic syndrome

M Magnone, L Sturla, L Guida, S Spinelli, G Begani… - Nutrients, 2020 - mdpi.com
Abscisic acid (ABA) is a hormone with a very long evolutionary history, dating back to the
earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely the …