Background NLRP3 inflammasome mediates IL-1β maturation, therefore plays a vital role in
the development of IBD. Curcumin is known for possessing strong anti-inflammatory …

Background: Ulcerative colitis (UC) is a chronic recurrent inflammatory bowel disease (IBD).
The conventional drugs for UC may induce severe side effects. Herbal medicine is …

Curcumin has a therapeutic effect on ulcerative colitis, but the underlying mechanism has
yet to be elucidated. The aim of the present study was to clarify the possible mechanisms …

Background and aims Although a series of studies have shown that curcumin can exert anti-
inflammatory effects in colitis by inhibiting NF-κB activation, whether these anti-inflammatory …

Scope The NLRP3 inflammasome responds to various pathogen‐derived factors and
danger‐associated molecules, mediating IL‐1β maturation, therefore is involved in multiple …

NLRP3 inflammasome has been reported to be associated with inflammatory bowel disease
including colitis due to its potential ability to induce IL-1β secretion. Emerging studies have …

A westernized high-fat diet (HFD) is associated with the development of inflammatory bowel
disease (IBD). High-level fecal deoxycholic acid (DCA) caused by HFD contributes to the …

Curcumin, an active ingredient of Curcumin longa mediates its anti-inflammatory effects
through inhibition of NFkB. Several pathways including toll-like receptors (TLR) induce NFkB …

Activation of cannabinoid receptor 2 (CB2R) ameliorates inflammation, but the underlying
mechanism remains unclear. In the present study, we examined whether activation of CB2R …

Curcumin has shown good efficacy in mice with experimental colitis and in patients with
ulcerative colitis, but the mechanism of action through the regulation of M1/M2 macrophage …