[HTML][HTML] Activation of cannabinoid receptor 2 ameliorates DSS-induced colitis through inhibiting NLRP3 inflammasome in macrophages
Activation of cannabinoid receptor 2 (CB2R) ameliorates inflammation, but the underlying
mechanism remains unclear. In the present study, we examined whether activation of CB2R …
mechanism remains unclear. In the present study, we examined whether activation of CB2R …
Curcumin ameliorates monosodium urate‐induced gouty arthritis through Nod‐like receptor 3 inflammasome mediation via inhibiting nuclear factor‐kappa B signaling
X Li, DQ Xu, DY Sun, T Zhang, X He… - Journal of Cellular …, 2019 - Wiley Online Library
Background Monosodium urate (MSU) crystals‐induced inflammation is a key initiator in
gouty arthritis. Curcumin is an active ingredient possessing anti‐inflammatory efficacy. But …
gouty arthritis. Curcumin is an active ingredient possessing anti‐inflammatory efficacy. But …
[HTML][HTML] Curcumin protects intestinal mucosal barrier function of rat enteritis via activation of MKP-1 and attenuation of p38 and NF-κB activation
WB Song, YY Wang, FS Meng, QH Zhang, JY Zeng… - PloS one, 2010 - journals.plos.org
Background Intestinal mucosa barrier (IMB) dysfunction results in many notorious diseases
for which there are currently few effective treatments. We studied curcumin's protective effect …
for which there are currently few effective treatments. We studied curcumin's protective effect …
[HTML][HTML] Curcumin represses NLRP3 inflammasome activation via TLR4/MyD88/NF-κB and P2X7R signaling in PMA-induced macrophages
F Kong, B Ye, J Cao, X Cai, L Lin, S Huang… - Frontiers in …, 2016 - frontiersin.org
Aims: In the NOD-like receptor (NLR) family, the pyrin domain containing 3 (NLRP3)
inflammasome is closely related to the progression of atherosclerosis. This study aimed to …
inflammasome is closely related to the progression of atherosclerosis. This study aimed to …
BBG enhances OLT1177-induced NLRP3 inflammasome inactivation by targeting P2X7R/NLRP3 and MyD88/NF-κB signaling in DSS-induced colitis in rats
Chronic ulceration of the colon is associated with the activation of TLR4/NF-κB and
P2X7R/NLRP3 signaling pathways. We investigated the effect of individual or combined …
P2X7R/NLRP3 signaling pathways. We investigated the effect of individual or combined …
Curcumin as a therapeutic agent for blocking NF-κB activation in ulcerative colitis
Y Wang, Q Tang, P Duan, L Yang - Immunopharmacology and …, 2018 - Taylor & Francis
Ulcerative colitis (UC) is a chronic, relapsing, remitting, and inflammatory disorder that
afflicts millions of people around the world. It carries a substantial economic burden …
afflicts millions of people around the world. It carries a substantial economic burden …
[HTML][HTML] Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis
Turmeric has been used as a medicinal herb for thousands of years for treatment of various
disorders. Although curcumin is the most studied active constituents of turmeric …
disorders. Although curcumin is the most studied active constituents of turmeric …
Paeoniflorin abrogates DSS-induced colitis via a TLR4-dependent pathway
J Zhang, W Dou, E Zhang, A Sun… - American Journal …, 2014 - journals.physiology.org
Paeonia lactiflora Pall is one of the most well-known herbs in China, Korea, and Japan for
more than 1,200 years. Paeoniflorin, the major bioactive component of peony root, has …
more than 1,200 years. Paeoniflorin, the major bioactive component of peony root, has …
Novel complementary coloprotective effects of metformin and MCC950 by modulating HSP90/NLRP3 interaction and inducing autophagy in rats
S Saber, EMA El-Kader - Inflammopharmacology, 2021 - Springer
Ulcerative colitis (UC) is a chronic and relapsing inflammatory disorder, which has an
increased incidence worldwide. The NLRP3 inflammasome has recently been assigned as …
increased incidence worldwide. The NLRP3 inflammasome has recently been assigned as …
[HTML][HTML] Resveratrol alleviates dextran sulfate sodium-induced acute ulcerative colitis in mice by mediating PI3K/Akt/VEGFA pathway
F Zhu, J Zheng, F Xu, Y Xi, J Chen, X Xu - Frontiers in pharmacology, 2021 - frontiersin.org
Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon, and its
incidence is on the rise worldwide. Resveratrol (RSV), a polyphenolic compound, was …
incidence is on the rise worldwide. Resveratrol (RSV), a polyphenolic compound, was …