Osteoarthritis (OA) is a degenerative joint disease and one of the leading causes of disability
in the United States and across the world. As a disease of the whole joint, OA exhibits a …

Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

Osteoarthritis (OA) is considered to be a complex illness in which the tissues of the joint play
a significant role in the initiation and/or progression of the pathophysiology. We still do not …

The subchondral bone is involved in the pathophysiology of osteoarthritis (OA), both by
biochemical and mechanical pathways. Overloaded OA subchondral bone osteoblasts …

Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Osteoarthritis (OA) is a major cause of pain and disability in the aging population, but its
pathogenesis remains incompletely understood. Alterations beneath the articular cartilage at …

The articular cartilage and the subchondral bone form a biocomposite that is uniquely
adapted to the transfer of loads across the diarthrodial joint. During the evolution of the …

Although cartilage degradation is the characteristic feature of osteoarthritis (OA), it is now
recognized that the whole joint is involved in the progression of OA. In particular, the …

Subchondral bone and articular cartilage play complementary roles in load bearing of the
joints. Although the biomechanical coupling between subchondral bone and articular …

Osteoarthritis (OA) is mainly caused by ageing, strain, trauma, and congenital joint
abnormalities, resulting in articular cartilage degeneration. During the pathogenesis of OA …