Accumulating epidemiological evidence shows that being either overweight or obese, in
other words having excess body weight (EBW), is associated with an increased risk of …

Obesity has reached epidemic proportions in the developed world. The progression from
obesity to diabetes mellitus type 2, via metabolic syndrome, is recognised, and the …

Epidemiological studies suggest a positive association between obesity and type 2 diabetes
mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance …

Obesity is associated with metabolic alterations that may pose a biological link between
body fatness and risk of cancer. Elucidating the role of obesity-related biomarkers in cancer …

This chapter posits that cancer is a complex and multifactorial process as demonstrated by
the expression and production of key endocrine and steroid hormones that intermesh with …

Abstract Insulin, IGF1, and IGF2 are the most studied insulin-like peptides (ILPs). These are
evolutionary conserved factors well known as key regulators of energy metabolism and …

Excess body weight (overweight and obesity) is characterized by chronic hyperinsulinaemia
and insulin resistance, and is implicated both in cancer risk and cancer mortality. The list of …

Obesity and type 2 diabetes (T2D) increase the prevalence and worsen the prognosis of
more than a dozen tumor types; however, the mechanism for this association remains hotly …

Body mass index, as an approximation of body adiposity, is associated with increased risk of
several common and less common malignancies in a sex-and site-specific manner. These …

For a century, since the pioneering work of Otto Warburg, the interwoven relationship
between metabolism and cancer has been appreciated. More recently, with obesity rates …