Synthesis, biological evaluation and molecular modeling studies of phthalazin-1 (2 H)-one derivatives as novel cholinesterase inhibitors
A new series of donepezil analogues based on the phthalazin-1 (2H)-one scaffold was
designed and synthesized with the aim of exploring its potential as human ChEIs. Biological …
designed and synthesized with the aim of exploring its potential as human ChEIs. Biological …
Phenyldiazenyl-phenoxy-1, 2, 3-triazol-acetamide derivatives as new dual cholinesterase Inhibitors: Design, synthesis, in vitro, and in silico enzymatic inhibition …
S Zareei, M Mohammadi-Khanaposhtani… - Journal of Molecular …, 2025 - Elsevier
In this work, phenyldiazenyl-phenoxy-1, 2, 3-triazol-acetamide as new scaffold was
designed by molecular hybridization of the active pharmacophores in the cholinesterase …
designed by molecular hybridization of the active pharmacophores in the cholinesterase …
Roles of hybrid donepezil scaffolds as potent human acetylcholinesterase inhibitors using in silico interaction analysis, drug-likeness, and pharmacokinetics prediction
P Honorio, S Hannongbua, P Saparpakorn - Chemico-Biological …, 2022 - Elsevier
Acetylcholinesterase (AChE) is currently one of the potent targets for the treatment of
Alzheimer's disease (AD). The discovery of promising new AChE inhibitors using a …
Alzheimer's disease (AD). The discovery of promising new AChE inhibitors using a …
In vitro and in silico correlation of benzoxazole-based thiazolidinone hybrids derivatives: A promising acetylcholinesterase and butyrylcholinesterase inhibitors
Benzoxazole-based thiazolidinone hybrids derivatives (1–19) were afforded and further
subjected to in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …
subjected to in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) …
6‐Methoxy‐1‐tetralone Derivatives Bearing an N‐Arylpyridinium Moiety as Cholinesterase Inhibitors: Design, Synthesis, Biological Evaluation, and Molecular Docking …
G Chehardoli, P Gholamhoseini, A Ebadi… - …, 2022 - Wiley Online Library
A novel series of 6‐methoxy‐1‐tetralone derivatives bearing N‐aryl pyridinium moiety were
designed, synthesized, and evaluated as acetyl and butyrylcholinesterase inhibitors. The …
designed, synthesized, and evaluated as acetyl and butyrylcholinesterase inhibitors. The …
Exploring 3-Benzyloxyflavones as new lead cholinesterase inhibitors: synthesis, structure–activity relationship and molecular modelling simulations
In this protocol, a series of 3-benzyloxyflavone derivatives have been designed,
synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The …
synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The …
Investigation of spirooxindole-pyrrolidine derivatives as acetylcholinesterase inhibitors using molecular docking/dynamics simulations, bioisosteric replacement, MEP …
Acetylcholinesterase is used as a key target in the treatment of Alzheimer's disease.
Recently, a series of new spirooxindolepyrrolidine derivatives were synthesized and …
Recently, a series of new spirooxindolepyrrolidine derivatives were synthesized and …
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes
Abstract Donepezil (DNP), an acetylcholinesterase (AChE) inhibitor, is one of the most
preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP …
preferred choices in Alzheimer diseases (AD) therapy. In the present study, 38 new DNP …
A new series of pyridazinone derivatives as cholinesterases inhibitors: Synthesis, in vitro activity and molecular modeling studies
Background The pyridazinone nucleus has been incorporated into a wide variety of
therapeutically interesting molecules to transform them into better drugs …
therapeutically interesting molecules to transform them into better drugs …
Quinoline containing chalcone derivatives as cholinesterase inhibitors and their in silico modeling studies
MS Shah, M Najam-ul-Haq, HS Shah, SUF Rizvi… - … Biology and Chemistry, 2018 - Elsevier
Cholinesterases (ChEs) play a vital role in regulating cholinergic transmission. Inhibition of
ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative …
ChEs is thought to be an emerging and useful therapeutic target for neurodegenerative …
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