To maintain intracellular redox homeostasis, genes encoding many antioxidants and
detoxification enzymes are transcriptionally upregulated upon deleterious oxidative stress …

Keap1 is a negative regulator of Nrf2, a bZIP transcription factor that mediates adaptation to
oxidative stress. Previous studies suggested this negative regulation is a consequence of …

Keap1 is an inhibitor of Nrf2 involved in Nrf2-dependent antioxidant response. However, the
mechanisms on how Keap1 regulates Nrf2-ARE signaling pathway remains to be …

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated
induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of …

The transcription factor Nrf2 regulates cellular redox homeostasis. Under basal conditions,
Keap1 recruits Nrf2 into the Cul3-containing E3 ubiquitin ligase complex for ubiquitin …

The bZIP transcription factor Nrf2 has emerged as a pivotal regulator of intracellular redox
homeostasis by controlling the expression of many endogenous antioxidants and phase II …

Nrf2 regulates the expression of genes encoding antioxidant proteins involved in cellular
redox homeostasis. Previous studies have suggested that activation of Nrf2 is mediated by …

Nrf2 is the key transcription factor regulating the antioxidant response. Nrf2 signaling is
repressed by Keap1 at basal condition and induced by oxidative stress. Keap1 is recently …

Nrf2, a basic leucine zipper transcription factor, is an essential activator of the coordinated
transcription of genes encoding antioxidant enzymes and phase II detoxifying enzymes …

The KEAP1-NRF2 system plays a central role in cytoprotection. NRF2 is stabilized in
response to electrophiles and activates transcription of antioxidant genes. Although robust …