Expression of antioxidant and phase 2 xenobiotic metabolizing enzyme genes is regulated
through cis-acting sequences known as antioxidant response elements. Transcriptional …

The capacity of cells to maintain homeostasis during oxidative stress resides in activation or
induction of protective enzymes. Nuclear-factor-E2-related factor (Nrf)-2 as a member of …

Basic leucine zipper (bZIP) protein Nrf2 is a key transcription factor mediating the antioxidant
response. Under homeostatic conditions Nrf2 is anchored to cysteine-rich Keap1 and …

Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …

A coordinated cellular response to oxidative stress occurs in part through transcriptional
regulation via a cis-acting sequence known as the antioxidant response element (ARE). NF …

The NRF2 transcription factor regulates a major environmental and oxidative stress
response. NRF2 is itself negatively regulated by KEAP1, the adaptor of a Cul3-ubiquitin …

In response to oxidative stress, Nrf2 and p21 Cip1/WAF1 are both upregulated to protect
cells from oxidative damage. Nrf2 is constantly ubiquitinated by a Keap1 dimer that interacts …

The antioxidant response element (ARE) and transcription factor Nrf2 regulate basal
expression and antioxidant induction of NAD (P) H: quinone oxidoreductase-1 (NQO1) and …

Antioxidant response element (ARE)-mediated expression and coordinated induction of
antioxidant enzymes is a critical mechanism of protection against chemically induced …

Human exposures to environmental toxicants have been associated with etiology of many
diseases including inflammation, cancer, and cardiovascular and neurodegenerative …