Nrf2 transcription factor can directly regulate mTOR: linking cytoprotective gene expression to a major metabolic regulator that generates redox activity
G Bendavit, T Aboulkassim, K Hilmi, S Shah… - Journal of Biological …, 2016 - ASBMB
Nrf2 is a master transcription factor that regulates a wide variety of cellular proteins by
recognizing and binding to antioxidant response elements (AREs) in their gene promoter …
recognizing and binding to antioxidant response elements (AREs) in their gene promoter …
Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism
KI Tong, A Kobayashi, F Katsuoka, M Yamamoto - 2006 - degruyter.com
Cells are equipped with a number of transcriptional factors that safeguard against various
environmental insults. Proteasomal protein degradation plays an important role in the Keap1 …
environmental insults. Proteasomal protein degradation plays an important role in the Keap1 …
[HTML][HTML] Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif
Nrf2 is the key transcription factor regulating the antioxidant response. When exposed to
oxidative stress, Nrf2 translocates to cell nucleus and forms heterodimer with small Maf …
oxidative stress, Nrf2 translocates to cell nucleus and forms heterodimer with small Maf …
Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2
J Pi, Y Bai, JM Reece, J Williams, D Liu… - Free Radical Biology …, 2007 - Elsevier
Nrf2 is a key transcription factor in the cellular response to oxidative stress. In this study we
identify two phosphorylated forms of endogenous human Nrf2 after chemically induced …
identify two phosphorylated forms of endogenous human Nrf2 after chemically induced …
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
M Biswas, JY Chan - Toxicology and applied pharmacology, 2010 - Elsevier
Oxidative stress plays an important part in the pathogenesis of a variety of diseases. The
ability to mount an efficient response against the continuous threat posed by exogenous and …
ability to mount an efficient response against the continuous threat posed by exogenous and …
[HTML][HTML] An important role of Nrf2-ARE pathway in the cellular defense mechanism
JM Lee, JA Johnson - BMB Reports, 2004 - koreascience.kr
The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes
encoding phase II detoxification enzymes and antioxidant proteins, such as NAD (P) H …
encoding phase II detoxification enzymes and antioxidant proteins, such as NAD (P) H …
Nrf2–Keap1 defines a physiologically important stress response mechanism
H Motohashi, M Yamamoto - Trends in molecular medicine, 2004 - cell.com
The transcription factor Nrf2 regulates the basal and inducible expression of numerous
detoxifying and antioxidant genes. The cytoplasmic protein Keap1 interacts with Nrf2 and …
detoxifying and antioxidant genes. The cytoplasmic protein Keap1 interacts with Nrf2 and …
Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene …
SK Niture, AK Jain, PM Shelton, AK Jaiswal - Journal of Biological …, 2011 - ASBMB
Nrf2 (NF-E2-related factor 2) is a nuclear transcription factor that in response to chemical
and radiation stress regulates coordinated induction of a battery of cytoprotective gene …
and radiation stress regulates coordinated induction of a battery of cytoprotective gene …
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
M McMahon, N Thomas, K Itoh, M Yamamoto… - Journal of Biological …, 2004 - ASBMB
The Nrf2 transcription factor is more rapidly turned over in cells grown under homeostatic
conditions than in those experiencing oxidative stress. The variable turnover of Nrf2 is …
conditions than in those experiencing oxidative stress. The variable turnover of Nrf2 is …
Canonical and non-canonical mechanisms of Nrf2 activation
CA Silva-Islas, PD Maldonado - Pharmacological research, 2018 - Elsevier
Abstract Nuclear Factor Erythroid 2-related factor 2 (Nrf2) is a transcription factor that
regulates the expression of genes involved in the metabolism, immune response, cellular …
regulates the expression of genes involved in the metabolism, immune response, cellular …