Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Y Katoh, K Itoh, E Yoshida, M Miyagishi… - Genes to …, 2001 - Wiley Online Library
Background Nrf2 belongs to the Cap‐N‐Collar (CNC) transcription factor family and is
essential for the antioxidant responsive element (ARE)‐mediated expression of a group of …
essential for the antioxidant responsive element (ARE)‐mediated expression of a group of …
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2
Q Ma, X He - Pharmacological reviews, 2012 - ASPET
Induction of drug-metabolizing enzymes through the antioxidant response element (ARE)-
dependent transcription was initially implicated in chemoprevention against cancer by …
dependent transcription was initially implicated in chemoprevention against cancer by …
The complexity of the Nrf2 pathway: beyond the antioxidant response
The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an
efficient and pivotal line of defensive to counteract environmental insults and endogenous …
efficient and pivotal line of defensive to counteract environmental insults and endogenous …
Nrf2, a multi‐organ protector?
JM Lee, J Li, DA Johnson, TD Stein, AD Kraft… - The FASEB …, 2005 - Wiley Online Library
ABSTRACT NF‐E2‐related factor 2 (Nrf2) is a basic leucine zipper transcription factor that
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …
binds to the promoter sequence “antioxidant responsive element (ARE)” leading to …
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
A Kobayashi, MI Kang, H Okawa, M Ohtsuji… - … and cellular biology, 2004 - Taylor & Francis
Transcription factor Nrf2 is a major regulator of genes encoding phase 2 detoxifying
enzymes and antioxidant stress proteins in response to electrophilic agents and oxidative …
enzymes and antioxidant stress proteins in response to electrophilic agents and oxidative …
Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism
M Velichkova, T Hasson - Molecular and cellular biology, 2005 - Taylor & Francis
Keap1 is a negative regulator of Nrf2, a transcription factor essential for antioxidant
response element (ARE)-mediated gene expression. We find that Keap1 sequesters Nrf2 in …
response element (ARE)-mediated gene expression. We find that Keap1 sequesters Nrf2 in …
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
[HTML][HTML] The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
LM Zipper, RT Mulcahy - Journal of Biological Chemistry, 2002 - ASBMB
Transactivation of phase II detoxification enzymes and antioxidant proteins is mediated by
the Cap'N′ Collar transcription factor, Nrf2, which is sequestered in the cytoplasm by the …
the Cap'N′ Collar transcription factor, Nrf2, which is sequestered in the cytoplasm by the …
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
S Numazawa, M Ishikawa, A Yoshida… - … of Physiology-Cell …, 2003 - journals.physiology.org
Transcription factor NF-E2-related factor 2 (Nrf2) regulates the induction of antioxidative
proteins, including heme oxygenase-1 (HO-1). Nrf2 is sequestered in the cytoplasm by …
proteins, including heme oxygenase-1 (HO-1). Nrf2 is sequestered in the cytoplasm by …
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
T Yamamoto, T Suzuki, A Kobayashi… - … and cellular biology, 2008 - Am Soc Microbiol
Keap1 and Cul3 constitute a unique ubiquitin E3 ligase that degrades Nrf2, a key activator of
cytoprotective genes. Upon exposure to oxidants/electrophiles, the enzymatic activity of this …
cytoprotective genes. Upon exposure to oxidants/electrophiles, the enzymatic activity of this …