The induction of many antioxidant and phase II drug-metabolizing enzymes by phenolic
antioxidants and electrophilic compounds is regulated at the transcriptional level. The …

Keap1 is a BTB‐Kelch substrate adaptor protein that regulates steady‐state levels of Nrf2, a
bZIP transcription factor, in response to oxidative stress. We have determined the structure of …

INrf2 tethering of the transcription factor Nrf2 in the cytosol prevents Nrf2 activation of
antioxidant response element (ARE) mediated gene expression. This investigation was …

Nrf2 is the regulator of the oxidative/electrophilic stress response. Its turnover is maintained
by Keap1-mediated proteasomal degradation via a two-site substrate recognition …

Publisher Summary This chapter outlines the role of Nrf2 in the activation of antioxidation
enzyme via antioxidant responsive element/electrophile responsive element (ARE/EpRE) …

Nrf2 accumulates in nuclei upon exposure to oxidative stress, heterodimerizes with a small
Maf protein, and activates the transcription of stress target genes through antioxidant …

NF-E2 related factor-2 (Nrf2) promotes the transcription of many cytoprotective genes and is
a major drug target for prevention of cancer and other diseases. Indeed, the cancer …

Nrf2 is a major transcription factor that significantly regulates—directly or indirectly—more
than 2000 genes. While many of these genes are involved in maintaining redox balance …

Nrf2 is a basic region leucine-zipper transcription factor that plays a pivotal role in the
coordinated gene expression of antioxidant and detoxifying enzymes, promoting cell …

The nuclear factor (erythroid 2)-like (NRF) transcription factors are a subset of cap'n'collar
transcriptional regulators. They consist of three members, NRF1, NRF2, and NRF3, that …