Transfection, a term derived from the phrase “infection by transformation,” is the process by
which foreign nucleic acids are introduced into cells. By this process, the phenotype of cells …

Dendrimers in RNAi Delivery Page 1 8 Dendrimers in RNAi Delivery Jose Luis Jiménez
Fuentes1, Paula Ortega2, Sara Ferrando-Martınez1, Rafael Gómez2, Manuel Leal3, Javier de …

Genetic therapies hold the promise of efficacious and safer therapies as they combine high
efficacy with the potential for excellent specificity based on the specific nature of the …

Dendrimers have unique molecular architectures and properties that make them attractive
materials for the development of nanomedicines. Key properties such as defined …

Over the last decades, gene therapy has emerged as a pioneering therapeutic approach to
treat or prevent several diseases. Among the explored strategies, the short-term silencing of …

A family of triazine dendrimers, differing in their core flexibility, generation number, and
surface functionality, was prepared and evaluated for its ability to accomplish RNAi. The …

There is a tremendous interest in moving siRNA therapeutics into a clinical setting for the
treatment of various diseases. This in itself however depends largely on the availability of …

siRNA technology presents a helpful means of gene silencing in mammalian cells.
Advancement in the field includes enhanced attentiveness in the characterization of target …

6 Conclusion This review has focused on the potential use of dendrimers, the combination of
dendrimers with other transfection techniques, and the use of dendrimer conjugates for DNA …

Synthetic polymers, such as dendrimers, play a critical role in pharmaceutical discovery and
development. Advances in the application of nanotechnology in medicine have given rise to …