Acetaminophen (APAP) is known to cause acute liver injury and acute liver failure in
Western countries. This study investigates the protective role of farnesol (FAR)(C15H26O), a …

Drug‐induced liver injury (DILI) is a frequent cause responsible for acute liver failure (ALF).
Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI. At high …

Background: Acetaminophen (APAP) is a safe and effective analgesic and antipyretic when
used at therapeutic levels. However, an acute or cumulative overdose can cause severe …

Acetaminophen (APAP) overdose causes acute liver injury or even death in both humans
and experimental animals. We investigated the effect of sesame oil on APAP-induced acute …

Acute liver injury is a common consequence of taking overdose of acetaminophen (APAP).
The aim of this study was to evaluate the antioxidant activity and hepatoprotective effect of a …

Oxidative stress is closely associated with acetaminophen (APAP)-induced toxicity. Heme
oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against …

Aim of the study: High dose acetaminophen (APAP) increases the risk of liver injury caused
by oxidative stress due to accumulation of reactive species. Although N-acetyl cysteine is the …

Abstract Acetaminophen (N-acetyl-p-aminophenol, APAP) is the most popular drug
recommended and consumed for relieving mild and moderate pain and fever. Although …

High doses of acetaminophen (APAP; N‐acetyl‐p‐aminophenol) cause severe
hepatotoxicity after metabolic activation by cytochrome P450 2E1. This study was …

Hepatotoxicity induced by acetaminophen (APAP)‐overdose is a major concern in clinical
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …