The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson'disease mice
Q Miao, Z Chai, LJ Song, Q Wang, GB Song… - Journal of …, 2022 - Elsevier
Parkinson's disease (PD) is a chronic and progressive movement disorder caused by the
selective loss of midbrain dopaminergic neurons of unknown etiology. Up to now, although …
selective loss of midbrain dopaminergic neurons of unknown etiology. Up to now, although …
Multiple mechanistic models reveal the neuroprotective effects of diterpene ginkgolides against astrocyte-mediated demyelination via the PAF-PAFR pathway
TJ Wang, ZY Wu, CH Yang, L Cao… - The American Journal …, 2022 - World Scientific
Currently, therapies for ischemic stroke are limited. Ginkgolides, unique Folium Ginkgo
components, have potential benefits for ischemic stroke patients, but there is little evidence …
components, have potential benefits for ischemic stroke patients, but there is little evidence …
[HTML][HTML] Dynamic balance of microglia and astrocytes involved in the remyelinating effect of ginkgolide B
JJ Yin, Y He, J An, Q Miao, RX Sui, Q Wang… - Frontiers in Cellular …, 2020 - frontiersin.org
Multiple sclerosis (MS) is an inflammatory demyelinating disorder in the central nervous
system (CNS), in which remyelination failure results in persistent neurologic impairment …
system (CNS), in which remyelination failure results in persistent neurologic impairment …
[HTML][HTML] Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone
Chinese herbal medicines (CHMs) have been used to treat human diseases for thousands
of years. Among them, Ginkgo biloba is reported to be beneficial to the nervous system and …
of years. Among them, Ginkgo biloba is reported to be beneficial to the nervous system and …
GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine intoxicated mice
LM Kosloski, EA Kosmacek, KE Olson… - Journal of …, 2013 - Elsevier
Innate and adaptive immune responses can speed nigrostriatal neurodegeneration in
Parkinson's disease (PD). We posit that GM-CSF can attenuate such responses. In 1-methyl …
Parkinson's disease (PD). We posit that GM-CSF can attenuate such responses. In 1-methyl …
Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis
QY Li, Q Miao, RX Sui, L Cao, CG Ma, BG Xiao… - International …, 2019 - Elsevier
Although several therapies are approved, none promote re-myelination in multiple sclerosis
(MS) patients, limiting their ability for sustained recovery. Thus, treatment development in MS …
(MS) patients, limiting their ability for sustained recovery. Thus, treatment development in MS …
A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury
J Wang, L Zhuang, Y Ding, Z Wang, W Xiao… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance There is substantial experimental evidence to support the
view that Ginkgo biloba L.(Ginkgoaceae), a traditional Chinese medicine known to treating …
view that Ginkgo biloba L.(Ginkgoaceae), a traditional Chinese medicine known to treating …
The Anti-Parkinson Potential of Gingko biloba-Supplement Mitigates Cortico-Cerebellar Degeneration and Neuropathobiological Alterations via Inflammatory and …
Activation of nuclear factor erythroid 2 related factor 2 (Nrf2) associated with the suppression
of various oxido-inflammatory pathways and the controller of several gene expressions …
of various oxido-inflammatory pathways and the controller of several gene expressions …
Ginkgolide B protects neurons from ischemic injury by inhibiting the expression of RTP801
X Wu, J Su, L Chen, B Ma, X Gu, L Zhu - Cellular and molecular …, 2015 - Springer
RTP801 (also known as REDD1), a stress-related protein, is induced by several
environmental stresses such as ischemia and cigarette smoke. Although ischemia can …
environmental stresses such as ischemia and cigarette smoke. Although ischemia can …
[HTML][HTML] Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced …
WST Chen, TY Lin, CH Kuo, DJY Hsieh… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a common disorder attributed to the loss of midbrain dopamine
(mDA) neurons and reduced dopamine secretion. Currently, the treatment regimes for PD …
(mDA) neurons and reduced dopamine secretion. Currently, the treatment regimes for PD …