The neuroprotective effects and transdifferentiation of astrocytes into dopaminergic neurons of Ginkgolide K on Parkinson'disease mice

Q Miao, Z Chai, LJ Song, Q Wang, GB Song… - Journal of …, 2022 - Elsevier
Parkinson's disease (PD) is a chronic and progressive movement disorder caused by the
selective loss of midbrain dopaminergic neurons of unknown etiology. Up to now, although …

Multiple mechanistic models reveal the neuroprotective effects of diterpene ginkgolides against astrocyte-mediated demyelination via the PAF-PAFR pathway

TJ Wang, ZY Wu, CH Yang, L Cao… - The American Journal …, 2022 - World Scientific
Currently, therapies for ischemic stroke are limited. Ginkgolides, unique Folium Ginkgo
components, have potential benefits for ischemic stroke patients, but there is little evidence …

[HTML][HTML] Dynamic balance of microglia and astrocytes involved in the remyelinating effect of ginkgolide B

JJ Yin, Y He, J An, Q Miao, RX Sui, Q Wang… - Frontiers in Cellular …, 2020 - frontiersin.org
Multiple sclerosis (MS) is an inflammatory demyelinating disorder in the central nervous
system (CNS), in which remyelination failure results in persistent neurologic impairment …

[HTML][HTML] Ginkgolide B promotes neuronal differentiation through the Wnt/β-catenin pathway in neural stem cells of the postnatal mammalian subventricular zone

MY Li, CT Chang, YT Han, CP Liao, JY Yu, TW Wang - Scientific reports, 2018 - nature.com
Chinese herbal medicines (CHMs) have been used to treat human diseases for thousands
of years. Among them, Ginkgo biloba is reported to be beneficial to the nervous system and …

GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine intoxicated mice

LM Kosloski, EA Kosmacek, KE Olson… - Journal of …, 2013 - Elsevier
Innate and adaptive immune responses can speed nigrostriatal neurodegeneration in
Parkinson's disease (PD). We posit that GM-CSF can attenuate such responses. In 1-methyl …

Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis

QY Li, Q Miao, RX Sui, L Cao, CG Ma, BG Xiao… - International …, 2019 - Elsevier
Although several therapies are approved, none promote re-myelination in multiple sclerosis
(MS) patients, limiting their ability for sustained recovery. Thus, treatment development in MS …

A RNA-seq approach for exploring the protective effect of ginkgolide B on glutamate-induced astrocytes injury

J Wang, L Zhuang, Y Ding, Z Wang, W Xiao… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance There is substantial experimental evidence to support the
view that Ginkgo biloba L.(Ginkgoaceae), a traditional Chinese medicine known to treating …

The Anti-Parkinson Potential of Gingko biloba-Supplement Mitigates Cortico-Cerebellar Degeneration and Neuropathobiological Alterations via Inflammatory and …

OG Adebayo, W Aduema, MU Emmanuel… - Neurochemical …, 2022 - Springer
Activation of nuclear factor erythroid 2 related factor 2 (Nrf2) associated with the suppression
of various oxido-inflammatory pathways and the controller of several gene expressions …

Ginkgolide B protects neurons from ischemic injury by inhibiting the expression of RTP801

X Wu, J Su, L Chen, B Ma, X Gu, L Zhu - Cellular and molecular …, 2015 - Springer
RTP801 (also known as REDD1), a stress-related protein, is induced by several
environmental stresses such as ischemia and cigarette smoke. Although ischemia can …

[HTML][HTML] Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced …

WST Chen, TY Lin, CH Kuo, DJY Hsieh… - Aging (Albany …, 2023 - ncbi.nlm.nih.gov
Parkinson's disease (PD) is a common disorder attributed to the loss of midbrain dopamine
(mDA) neurons and reduced dopamine secretion. Currently, the treatment regimes for PD …