[HTML][HTML] 20 (S)-protopanaxadiol promotes the migration, proliferation, and differentiation of neural stem cells by targeting GSK-3β in the Wnt/GSK-3β/β-catenin …

K Lin, B Liu, SL Lim, X Fu, SCW Sze, KKL Yung… - Journal of Ginseng …, 2020 - Elsevier
Background Active natural ingredients, especially small molecules, have recently received
wide attention as modifiers used to treat neurodegenerative disease by promoting …

Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 …

Y Zhang, JM Miao - European journal of pharmacology, 2018 - Elsevier
Ischemic stroke is the leading cause of death around the world. Ginkgolide K (GK) has been
used to treat ischemic stroke due to its neuroprotective potential. However, the molecular …

[HTML][HTML] Neuroprotection against Parkinson's disease through the activation of akt/gsk3β signaling pathway by Tovophyllin A

Y Huang, L Sun, S Zhu, L Xu, S Liu, C Yuan… - Frontiers in …, 2020 - frontiersin.org
Parkinson's disease (PD) is one of the most prevalent and life-threatening
neurodegenerative disease and mainly characterized by lack of sufficient dopaminergic …

[HTML][HTML] Uncovering the pharmacology of Ginkgo biloba folium in the cell-type-specific targets of Parkinson's disease

YC Yan, ZH Xu, J Wang, WB Yu - Frontiers in Pharmacology, 2022 - frontiersin.org
Parkinson's disease (PD) is the second most common neurodegenerative disease with a
fast-growing prevalence. Developing disease-modifying therapies for PD remains an …

[HTML][HTML] Comparing the role of Ginkgolide B and Ginkgolide K on cultured astrocytes exposed to oxygen-glucose deprivation

WB Yu, L Cao, YY Zhao, W Xiao… - Molecular Medicine …, 2018 - spandidos-publications.com
Ginkgolide B (GB) and ginkgolide K (GK) are two main active monomers of ginkgolides that
present a unique group of diterpenes found naturally in the leaves of the Ginkgo biloba tree …

Ginsenoside Rg1 exerts neuroprotective effects in 3-nitropronpionic acid-induced mouse model of Huntington's disease via suppressing MAPKs and NF-κB pathways …

X Yang, S Chu, Z Wang, F Li, Y Yuan… - Acta Pharmacologica …, 2021 - nature.com
Huntington's disease (HD) is one of main neurodegenerative diseases, characterized by
striatal atrophy, involuntary movements, and motor incoordination. Ginsenoside Rg1 (Rg1) …

[HTML][HTML] Neuroprotection by immunomodulatory agents in animal models of Parkinson's disease

B Martinez, PV Peplow - Neural Regeneration Research, 2018 - journals.lww.com
Parkinson's disease (PD) is an age-related neurodegenerative disease for which the
characteristic motor symptoms emerge after an extensive loss of dopamine containing …

Ginkgolide B protects against ischemic stroke via modulating microglia polarization in mice

ZM Shu, XD Shu, HQ Li, Y Sun, H Shan… - CNS neuroscience & …, 2016 - Wiley Online Library
Summary Aim Ginkgolide B (GB) has shown neuroprotective effect in treating ischemic
stroke, related to its property of anti‐inflammation. Nevertheless, it is unclear whether GB is …

Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation

R Zhang, S Xu, Y Cai, M Zhou, X Zuo… - Evidence‐Based …, 2011 - Wiley Online Library
Abundant evidence has suggested that neuroinflammation participates in the pathogenesis
of Parkinson′ s disease (PD). The emerging evidence has supported that microglia may …

[HTML][HTML] Ginkgolide B‑induced AMPK pathway activation protects astrocytes by regulating endoplasmic reticulum stress, oxidative stress and energy metabolism …

J Wang, Y Ding, L Zhuang… - Molecular …, 2021 - spandidos-publications.com
Ginkgolide B (GB), the diterpenoid lactone compound isolated from the extracts of Ginkgo
biloba leaves, significantly improves cognitive impairment, but its potential pharmacological …