[HTML][HTML] Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson's disease model

J Yan, Z Yang, N Zhao, Z Li, X Cao - Bmc Neuroscience, 2019 - Springer
Background Recently, the use of traditional Chinese medicine (TCM) has become more
generally accepted, including by the Food and Drug Administration. To expand the use of …

Galectin-1 attenuates neurodegeneration in Parkinson's disease model by modulating microglial MAPK/IκB/NFκB axis through its carbohydrate-recognition domain

Y Li, N Chen, C Wu, Y Lu, G Gao, C Duan… - Brain, Behavior, and …, 2020 - Elsevier
The vicious cycle between the chronic activation of microglia and dopamine neurons
degeneration is linked with the progression of Parkinson's disease (PD). Targeting …

[HTML][HTML] Galangin reduces the loss of dopaminergic neurons in an LPS-evoked model of Parkinson's disease in rats

G Chen, J Liu, L Jiang, X Ran, D He, Y Li… - International journal of …, 2017 - mdpi.com
Parkinson's disease (PD) is caused by the loss of dopaminergic (DA) neurons in the
midbrain substantia nigra (SN). Neuroinflammation, which is marked by microglial activation …

Protection of MPTP-induced neuroinflammation and neurodegeneration by rotigotine-loaded microspheres

X Yu, JY Yao, J He, JW Tian - Life sciences, 2015 - Elsevier
Aims The aim of the study is to evaluate the neuroprotective effects of continuous
dopaminergic stimulation (CDS) by rotigotine-loaded microspheres (RoMS) in a mouse …

Echinacoside protects dopaminergic neurons by inhibiting NLRP3/Caspase-1/IL-1β signaling pathway in MPTP-induced Parkinson's disease model

MR Gao, M Wang, YY Jia, DD Tian, A Liu, WJ Wang… - Brain research …, 2020 - Elsevier
Persistent microglia-mediated neuroinflammation contributes to the progressive loss of
dopaminergic (DA) neurons in Parkinson's disease (PD). Recently, NOD-like receptor …

FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation

S Yao, L Li, X Sun, J Hua, K Zhang, L Hao, L Liu… - Journal of neuroimmune …, 2019 - Springer
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons
and excessive microglial activation in the substantia nigra pars compacta (SNpc). In the …

[HTML][HTML] Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways

X Zhang, M Shi, M Bjørås, W Wang, G Zhang… - Frontiers in …, 2013 - frontiersin.org
Ginsenoside Rd (Rd), one of the main active ingredients in Panax ginseng, has been
showed to protect against ischemic cerebral damage both in vitro and in vivo. However, the …

Gastrodin promotes hippocampal neurogenesis via PDE9-cGMP-PKG pathway in mice following cerebral ischemia

H Xiao, Q Jiang, H Qiu, K Wu, X Ma, J Yang… - Neurochemistry …, 2021 - Elsevier
Gastrodin, which is extracted from the Chinese herbal medicine Gastrodia elata Blume, can
ameliorate neurogenesis after cerebral ischemia. However, it's possible underlying …

Korean red ginseng and ginsenoside-Rb1/-Rg1 alleviate experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating …

MJ Lee, M Jang, J Choi, BS Chang, DY Kim… - Molecular …, 2016 - Springer
The effects of Korean red ginseng extract (KRGE) on autoimmune disorders of the nervous
system are not clear. We investigated whether KRGE has a beneficial effect on acute and …

Synthesis, biological activity evaluation and mechanism analysis of new ganglioside GM3 derivatives as potential agents for nervous functional recovery

Y Lin, J Wang, X Liu, Y Hu, Y Zhang, F Jiang - European Journal of …, 2024 - Elsevier
Neuronal regenerative ability is vital for the treatment of neurodegenerative diseases and
neuronal injuries. Recent studies have revealed that Ganglioside GM3 and its derivatives …