AIM: To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in
genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9, tissue inhibitors of …

Increased production of matrix metalloproteinases (MMPs) plays an important role in tissue
damage in inflammatory bowel disease (IBD). Genetically encoded variation between …

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are
thought to be predominant proteases and protease inhibitors involved in the pathogenesis of …

Inflammatory bowel disease (IBD) is a complex, multifactorial, chronic inflammatory disorder
of the gastrointestinal tract in which immune dysregulation caused by genetic and/or …

Strong evidence indicates that inflammatory bowel disease, including Crohn disease and
ulcerative colitis, is a result of an inappropriate inflammatory response in which genetic and …

THE mechanisms responsible for development of inflammatory bowel disease (IBD) have
not been fully elucidated, although the main cause of disease pathology is attributed to up …

Background Previous studies have shown an upregulation of matrix metalloproteinases
(MMPs) in intestinal tissue of patients with inflammatory bowel disease (IBD) and significant …

Crohn's disease (CD) and ulcerative colitis (UC) are types of chronic inflammatory bowel
disease (IBD) of which the actual causes remain unknown. Emerging data indicate that …

AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of
the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel …

Background Recurrence of disease after surgically induced remission constitutes a major
and largely unpredictable problem in Crohn's disease (CD). Matrix metalloproteinases …