Drosophila melanogaster has become a significant model organism for alcohol research. In
flies, a rich variety of behaviors can be leveraged for identifying genes affecting alcohol …

Drosophila melanogaster is commonly found near rotting or fermenting fruit, reflected in its
name pomace, or vinegar fly. In such environments, flies often encounter significant levels of …

Alcohol is a widely used and abused substance with numerous negative consequences for
human health and safety. Historically, alcohol's widespread, non-specific neurobiological …

Ethanol intake causes gene expression changes resulting in cellular and molecular
adaptations that could be associated with a predisposition to alcohol dependence. Recently …

Background Alcohol abuse and alcoholism are significant public health problems, but the
genetic basis for individual variation in alcohol sensitivity remains poorly understood …

Researchers frequently study the fruit fly Drosophila melanogaster as a model system for
mammalian development and behavior. Drosophila appear resistant to alcohol's toxic effects …

Our understanding of alcohol use disorder (AUD), particularly alcohol's effects on the
nervous system, has unquestionably benefited from the use of model systems such as …

Identification of risk alleles for human behavioral disorders through genomewide association
studies (GWAS) has been hampered by a daunting multiple testing problem. This problem …

Background Alcoholism is a complex disorder determined by interactions between genetic
and environmental risk factors. Drosophila represents a powerful model system to dissect …

Background: In most organisms in which acute ethanol exposure has been studied, it leads
to similar changes in behavior. Generally, low ethanol doses activate the central nervous …