The complex of ferric-enterobactin with its transporter from Pseudomonas aeruginosa suggests a two-site model

L Moynié, S Milenkovic, GLA Mislin, V Gasser… - Nature …, 2019 - nature.com
Bacteria use small molecules called siderophores to scavenge iron. Siderophore-Fe3+
complexes are recognised by outer-membrane transporters and imported into the periplasm …

Siderophores: biochemical ecology and mechanism of iron transport in enterobacteria

JB Neilands - 1977 - ACS Publications
Siderophores protect Escherichia coli and Salmonella typhimurium from certain phages,
bacteriocins, and antibiotics by two mechanisms. The first is adsorption competition for outer …

Corynebactin and a serine trilactone based analogue: chirality and molecular modeling of ferric complexes

ME Bluhm, BP Hay, SS Kim, EA Dertz… - Inorganic …, 2002 - ACS Publications
Because the hydrolysis of ferric ion makes it very insoluble in aerobic, near neutral pH
environments, most species of bacteria produce siderophores to acquire iron, an essential …

Role of catecholate siderophores in gram-negative bacterial colonization of the mouse gut

H Pi, SA Jones, LE Mercer, JP Meador, JE Caughron… - PLoS …, 2012 - journals.plos.org
We investigated the importance of the production of catecholate siderophores, and the
utilization of their iron (III) complexes, to colonization of the mouse intestinal tract by …

A site-directed spin-labeling study of ligand-induced conformational change in the ferric enterobactin receptor, FepA

J Liu, JM Rutz, PE Klebba, JB Feix - Biochemistry, 1994 - ACS Publications
Revised Manuscript Received September 6, 19940 abstract: The ferric enterobactin
receptor, FepA, is a TonB-dependent gated porin that transports the siderophore ferric …

Siderophore-Mediated Cargo Delivery to the Cytoplasm of Escherichia coli and Pseudomonas aeruginosa: Syntheses of Monofunctionalized Enterobactin Scaffolds …

T Zheng, JL Bullock, EM Nolan - Journal of the American …, 2012 - ACS Publications
The design and syntheses of monofunctionalized enterobactin (Ent, l-and d-isomers)
scaffolds where one catecholate moiety of enterobactin houses an alkene, aldehyde, or …

Bacterial colonization of nasal mucosa induces expression of siderocalin, an iron‐sequestering component of innate immunity

AL Nelson, JM Barasch, RM Bunte… - Cellular …, 2005 - Wiley Online Library
Host–microbe interactions often begin with colonization of mucosal surfaces. These
relationships are highly specific, as certain microbial species are found only in particular …

Substituted complexes of enterobactin and synthetic analogs as probes of the ferric-enterobactin receptor in Escherichia coli

DJ Ecker, LD Loomis, ME Cass… - Journal of the American …, 1988 - ACS Publications
The structural requirements for recognition of ferric-enterobactin by the ferric-enterobactin
receptor in Escherichia coli have been examined with model complexes as probes in …

Effect of metal binding on the conformation of enterobactin. Proton and carbon-13 nuclear magnetic resonance study

M Llinas, DM Wilson, JB Neilands - Biochemistry, 1973 - ACS Publications
M. Llinás,* DM Wilson,| and JB Neilands abstract: The conformations of enterobactin and its
Ga3+ chelate dissolved in (CD3) 2SO have been characterized by and 13C nmr. All the …

The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2

MA Fischbach, H Lin, L Zhou, Y Yu… - Proceedings of the …, 2006 - National Acad Sciences
Numerous bacteria cope with the scarcity of iron in their microenvironment by synthesizing
small iron-scavenging molecules known as siderophores. Mammals have evolved …