Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells
Animal cells have recently been shown to express a range of∼ 22 nucleotide noncoding
RNAs termed micro RNAs (miRNAs). Here, we show that the human mir-30 miRNA can be …
RNAs termed micro RNAs (miRNAs). Here, we show that the human mir-30 miRNA can be …
Sequence requirements for micro RNA processing and function in human cells
Y Zeng, BR Cullen - Rna, 2003 - rnajournal.cshlp.org
Most eukaryotes encode a substantial number of small noncoding RNAs termed micro RNAs
(miRNAs). Previously, we have demonstrated that miR-30, a 22-nucleotide human miRNA …
(miRNAs). Previously, we have demonstrated that miR-30, a 22-nucleotide human miRNA …
Use of RNA polymerase II to transcribe artificial microRNAs
Y Zeng, X Cai, BR Cullen - Methods in enzymology, 2005 - Elsevier
MicroRNAs (miRNAs) are endogenously encoded∼ 22-nt-long RNAs that are generally
expressed in a highly tissue-or developmental-stage-specific fashion and that …
expressed in a highly tissue-or developmental-stage-specific fashion and that …
Transfection of microRNA mimics should be used with caution
HY Jin, A Gonzalez-Martin, AV Miletic, M Lai… - Frontiers in …, 2015 - frontiersin.org
Transient transfection of chemically synthesized microRNA (miRNA) mimics is being used
extensively to study the functions and mechanisms of endogenous miRNAs. However, it …
extensively to study the functions and mechanisms of endogenous miRNAs. However, it …
MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
MicroRNAs (miRNAs) are endogenously encoded small noncoding RNAs, derived by
processing of short RNA hairpins, that can inhibit the translation of mRNAs bearing partially …
processing of short RNA hairpins, that can inhibit the translation of mRNAs bearing partially …
Post-transcriptional regulation of microRNA expression
G Obernosterer, PJF Leuschner, M Alenius, J Martinez - Rna, 2006 - rnajournal.cshlp.org
microRNAs (miRNAs) are endogenous, noncoding∼ 22-nucleotide RNA molecules that
have recently emerged as fundamental, post-transcriptional regulators of cognate target …
have recently emerged as fundamental, post-transcriptional regulators of cognate target …
[HTML][HTML] Mammalian 5′-capped microRNA precursors that generate a single microRNA
MicroRNAs (miRNAs) are short RNA gene regulators typically produced from primary
transcripts that are cleaved by the nuclear microprocessor complex, with the resulting …
transcripts that are cleaved by the nuclear microprocessor complex, with the resulting …
Biogenesis of mammalian microRNAs: a global view
P Graves, Y Zeng - Genomics, Proteomics and Bioinformatics, 2012 - academic.oup.com
Abstract MicroRNAs (miRNAs) are approximately 22-nucleotide-long non-coding RNAs that
are important regulators of gene expression in eukaryotes. miRNAs are first transcribed as …
are important regulators of gene expression in eukaryotes. miRNAs are first transcribed as …
Transcriptional gene silencing in mammalian cells by miRNA mimics that target gene promoters
ST Younger, DR Corey - Nucleic acids research, 2011 - academic.oup.com
Synthetic small duplex RNAs that are fully complementary to gene promoters can silence
transcription in mammalian cells. microRNAs (miRNAs) are endogenous small regulatory …
transcription in mammalian cells. microRNAs (miRNAs) are endogenous small regulatory …
Design and delivery of antisense oligonucleotides to block microRNA function in cultured Drosophila and human cells
MD Horwich, PD Zamore - Nature protocols, 2008 - nature.com
Abstract MicroRNAs (miRNAs),∼ 22-nt RNAs that mediate post-transcriptional regulation of
mRNAs in animals and plants, are a diverse class of regulatory genes whose specific …
mRNAs in animals and plants, are a diverse class of regulatory genes whose specific …