Role of glutamatergic system in obsessive-compulsive disorder with possible therapeutic implications

P Vlček, J Polák, M Brunovský… - Pharmacopsychiatry, 2018 - thieme-connect.com
Obsessive-compulsive disorder (OCD) is a chronic psychiatric illness and 1 of the most
common anxiety disorders with the prevalence of 3%. Although its pathogenesis remains …

Glutamate-modulating drugs as a potential therapeutic strategy in obsessive-compulsive disorder

Z Marinova, DM Chuang… - Current …, 2017 - ingentaconnect.com
Objective: Obsessive-compulsive disorder (OCD) is a mental disease commonly associated
with severe distress and impairment of social functioning. Serotonin reuptake inhibitors …

Obsessive compulsive disorder and the glutamatergic system

C Kariuki-Nyuthe, B Gomez-Mancilla… - Current opinion in …, 2014 - journals.lww.com
Given the need for more efficacious treatments in OCD, and given emergent findings on the
role of the glutamatergic system in this disorder, there is a need for additional …

Memantine augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial

E Aboujaoude, JJ Barry, N Gamel - Journal of clinical …, 2009 - journals.lww.com
Background: Data from the fields of genetics, neuroimaging, and animal studies, along with
case reports and small clinical trials, point to a role for glutamatergic dysfunction in the …

[PDF][PDF] Glutamatergic dysfunction in obsessive-compulsive disorder and the potential clinical utility of glutamate-modulating agents

C Pittenger, M Bloch, R Wegner, C Teitelbaum… - Primary …, 2006 - researchgate.net
Obsessive-compulsive disorder (OCD) is a common psychiatric disorder and the tenth
leading cause of disability in the world. The introduction of serotonin reuptake inhibitors …

On the role of cortical glutamate inobsessive‐compulsive disorder and attention‐deficit hyperactivity disorder, two phenomenologically antithetical conditions

ML Carlsson - Acta Psychiatrica Scandinavica, 2000 - Wiley Online Library
Objective: The objective of the present study was to compare the phenomenology and
pathophysiology of obsessive‐compulsive disorder (OCD) and attention‐deficit hyperactivity …

On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder

ML Carlsson - Progress in Neuro-Psychopharmacology and …, 2001 - Elsevier
The objective of the present study was to compare the phenomenology and pathophysiology
of obsessive compulsive disorder (OCD) and attention deficit hyperactivity disorder/deficits …

Glutamate abnormalities in obsessive compulsive disorder: neurobiology, pathophysiology, and treatment

C Pittenger, MH Bloch, K Williams - Pharmacology & therapeutics, 2011 - Elsevier
Obsessive compulsive disorder is prevalent, disabling, incompletely understood, and often
resistant to current therapies. Established treatments consist of specialized cognitive …

Metabotropic glutamate receptor 5 binding in patients with obsessive-compulsive disorder

F Akkus, S Terbeck, SM Ametamey… - International Journal …, 2014 - academic.oup.com
Obsessive-compulsive disorder (OCD) is a disabling, mostly chronic, psychiatric condition
with significant social and economic impairments and is a major public health issue …

Amantadine as adjuvant therapy in the treatment of moderate to severe obsessive–compulsive disorder: a double‐blind randomized trial with placebo control

S Naderi, H Faghih, A Aqamolaei… - Psychiatry and …, 2019 - Wiley Online Library
Aim The role of the glutamatergic system in the pathogenesis of obsessive–compulsive
disorder (OCD) has been shown by numerous studies. The aim of the present randomized …