Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by various cellular
stresses, as well as in response to inflammatory cytokines. In the central nervous systems …

Protein kinases are critical modulators of a variety of cellular signal transduction pathways,
and abnormal phosphorylation events can be a cause or contributor to disease progression …

The trigger and etiology of chronic inflammatory diseases are not well understood, hindering
the development of efficient therapeutic approaches. The observation that abnormal activity …

During the last two decades, many p38α mitogen-activated protein kinase (p38α MAPK)
inhibitors have been developed and tested in preclinical/clinical studies for the treatment of …

Accumulating evidence indicates that p38 mitogen-activated protein kinase (MAPK) could
play more than one role in Alzheimer's disease (AD) pathophysiology and that patients …

P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory
diseases. Alzheimer's disease (AD) is characterized by the presence of amyloid plaques …

p38 mitogen-activated protein kinases (p38 MAPK, p38) consist of 4 subunits: p38α, p38β,
p38γ and p38δ. They play a well-recognized role in regulating intracellular signaling …

Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …

Background: The p38 mitogen-activated protein kinase (MAPK) is activated by various pro-
inflammatory and stressful stimuli. Mounting evidence suggests that the p38 MAPK signaling …

Inflammation in the central nervous system (CNS) is a common feature of age-related
neurodegenerative diseases. Proinflammatory cytokines, such as IL-1β and TNFα, are …