Mammalian p38 mitogen-activated protein kinases (MAPKs) are activated by a wide range
of cellular stresses as well as in response to inflammatory cytokines. There are four …

The activation of p38 mitogen-activated protein kinases (MAPKs) has been implicated in
many cellular processes, such as, inflammation, cell death, and survival. In mammals, four …

p38 Mitogen-activated protein kinase (p38 MAPK) is expressed in the oligodendrocyte
lineage, and its activity has been implicated in the proliferation and transition of early …

A novel structural class of p38α MAP kinase inhibitors has been identified via iterative SAR
studies of a focused deck screen hit. Optimization of the lead series generated 6e, BMS …

The p38 mitogen‐activated protein kinase (MAPK) is induced in response to environmental
stress. Although p38 MAPK has been implicated in diverse cellular processes, including cell …

p38MAPK has been implicated in the regulation of proinflammatory cytokines and apoptosis
in vitro. To understand its role in neurodegeneration, we determined the time course and …

The inflammatory response in the brain is closely associated with the pathogenesis of
degenerative neurological disorders. A role for the p38 stress‐activated protein …

A greater understanding of the mechanisms that promote the survival and growth of
dopaminergic neurons is essential for the advancement of cell replacement therapies for …

The stress-activated mitogen-activated protein kinase (MAPK) p38 has been linked to the
production of inflammatory cytokines/mediators/inflammation and death/apoptosis following …

The p38 MAPK signalling pathway plays an important role in inflammation and other
physiological processes. Specific inhibitors of p38 α and β MAPK block production of the …