The p38 MAPK signalling pathway plays an important role in inflammation and other
physiological processes. Specific inhibitors of p38 α and β MAPK block production of the …

The initial disclosure of tri-substituted imidazole-based drug molecules such as 1 for
inhibition of p38 MAP kinase by SmithKline Beecham (SB) sparked an effort in this area at …

It has now been almost 20 years since the discovery of p38 MAP kinase and its role in
inflammatory cytokine synthesis through reverse pharmacology and its subsequent …

p38 MAPK is a Ser/Thr protein kinase activated by various inflammatory cytokines and a
variety of stress stimuli. It is involved in many physiological processes, including the …

Activation of p38 mitogen-activated protein kinase (p38 MAPK) has been implicated in
pathological changes in inflammatory and apoptotic processes in various cell types …

The p38α mitogen-activated protein (MAP) kinase is a central signaling molecule in many
proinflammatory pathways, regulating the cellular response to a multitude of external stimuli …

Neuropathological lesions in Alzheimer's disease (AD) include amyloid plaques formed by
the accumulation of amyloid peptides, neurofibrillary tangles made of hyperphosphorylated …

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

Introduction The mitogen-activated protein kinase (MAPK) family consist of p38 MAP
kinases, c-Jun N-terminal kinases (JNKs) and extracellular signal-regulated kinases (ERKs) …

Novel potent trisubstituted pyridazine inhibitors of p38 MAP (mitogen activated protein)
kinase are described that have activity in both cell-based assays of cytokine release and …