Polyacrylate-based delivery system for self-adjuvanting anticancer peptide vaccine

TY Liu, WM Hussein, AK Giddam, Z Jia… - Journal of medicinal …, 2015 - ACS Publications
Vaccination can provide a safe alternative to chemotherapy by using the body's natural
defense mechanisms to create a potent immune response against tumor cells. Peptide …

Self-adjuvanting therapeutic peptide-based vaccine induce CD8+ cytotoxic T lymphocyte responses in a murine human papillomavirus tumor model

TY Liu, A Kumar Giddam, WM Hussein… - Current drug …, 2015 - ingentaconnect.com
Vaccine candidates for the treatment of human papillomavirus (HPV)-associated cancers
are aimed to activate T-cells and induce development of cytotoxic anti-tumor specific …

Self-assembling peptide epitopes as novel platform for anticancer vaccination

M Rad-Malekshahi, MF Fransen… - Molecular …, 2017 - ACS Publications
The aim of the present study was to improve the immunogenicity of peptide epitope vaccines
using novel nanocarriers based on self-assembling materials. Several studies demonstrated …

Multiantigenic peptide–polymer conjugates as therapeutic vaccines against cervical cancer

WM Hussein, TY Liu, Z Jia, NAJ McMillan… - Bioorganic & medicinal …, 2016 - Elsevier
Immunotherapy is one of the most promising strategies for the treatment of cancer. Human
papillomavirus (HPV) is responsible for virtually all cases of cervical cancer. The main …

Multifunctional protein conjugates with built-in adjuvant (adjuvant-protein-antigen) as cancer vaccines boost potent immune responses

JJ Du, CW Wang, WB Xu, L Zhang, YK Tang, SH Zhou… - Iscience, 2020 - cell.com
Many cancer vaccines are not successful in clinical trials, mainly due to the challenges
associated with breaking immune tolerance. Herein, we report a new strategy using an …

Improving the efficacy of peptide vaccines in cancer immunotherapy

F Zahedipour, K Jamialahmadi, P Zamani… - International …, 2023 - Elsevier
Peptide vaccines have shown great potential in cancer immunotherapy by targeting tumor
antigens and activating the patient's immune system to mount a specific response against …

[PDF][PDF] Liposomal formulation of polyacrylate-peptide conjugate as a new vaccine candidate against cervical cancer

M Khongkow, TY Liu, S Bartlett… - Precision …, 2018 - precisionnanomedicine.com
Peptide-based vaccines have been proposed as a therapeutic strategy for many infectious
diseases, including human papilloma virus (HPV)-related cervical cancer. Peptide-based …

[HTML][HTML] Self-assembling, self-adjuvanting and fully synthetic peptide nanovaccine for cancer immunotherapy

H Song, Q Su, P Huang, C Zhang, W Wang - Smart Materials in Medicine, 2021 - Elsevier
Cancer vaccines designed to initiate or amplify tumor-specific T-cell responses have been
used as a key approach for effective cancer immunotherapy. Across the history of tumor …

Precisely shaped self-adjuvanting peptide vaccines with enhanced immune responses for HPV-associated cancer therapy

Y Song, Q Su, H Song, X Shi, M Li, N Song… - … Applied Materials & …, 2021 - ACS Publications
Peptide vaccines exhibit great potential in cancer therapy via eliciting antigen-specific host
immune response and long-term immune memory to defend cancer cells. However, the low …

Synthetic, Supramolecular, and Self‐Adjuvanting CD8+ T‐Cell Epitope Vaccine Increases the Therapeutic Antitumor Immunity

P Yang, H Song, Z Feng, C Wang… - Advanced …, 2019 - Wiley Online Library
Peptide vaccines are used in clinical cancer immunotherapy, however, they generally suffer
from suboptimal immunogenicity compared to live or inactive virus vector vaccines or …