Rhodamine‐Ethylenediol, A Novel Vital Fluorescent Probe for Labelling Alkaline Phosphatase‐Rich Organelles

YH Chen, CH Chiou, WL Chen, YR Jhou… - Journal of the …, 2010 - Wiley Online Library
Zebrafish have received considerable attention as an organism‐based model in the
development of pharmacological agents. 1, 2 Many small molecules applied to zebrafish …

A fluorescent turn-on probe for the detection of alkaline phosphatase activity in living cells

TI Kim, H Kim, Y Choi, Y Kim - Chemical Communications, 2011 - pubs.rsc.org
A fluorescent turn-on probe for the detection of alkaline phosphatase activity in living cells -
Chemical Communications (RSC Publishing) DOI:10.1039/C1CC13819G Royal Society of …

Fluorogenic assay of alkaline phosphatase activity based on the modulation of excited-state intramolecular proton transfer

J Park, A Helal, HS Kim, Y Kim - Bioorganic & medicinal chemistry letters, 2012 - Elsevier
A new fluorogenic substrate 1, which enables the fast and quantitative analysis of alkaline
phosphatase activity, has been developed. Selective enzymatic hydrolysis of 1 instantly …

An enzyme-activatable probe with a self-immolative linker for rapid and sensitive alkaline phosphatase detection and cell imaging through a cascade reaction

H Zhang, C Xu, J Liu, X Li, L Guo, X Li - Chemical Communications, 2015 - pubs.rsc.org
We report the design and synthesis of a novel probe (1) for ALP assay by incorporating a
self-immolative linker between a phosphate moiety and resorufin. Because of its good …

A fluorescent turn-on probe based on isophorone for the rapid detection of alkaline phosphatase and its application in bioimaging

J Li, F Huo, Z Wen, C Yin - Spectrochimica Acta Part A: Molecular and …, 2019 - Elsevier
Biological species analyses on account of fluorescence detection technology are receiving
increasing attention, because they combine the advantages both powerful detection …

A ratiometric fluorescent probe for quantification of alkaline phosphatase in living cells

Z Lu, J Wu, W Liu, G Zhang, P Wang - RSC advances, 2016 - pubs.rsc.org
A ratiometric fluorescent probe with strong intramolecular charge transfer (ICT) character
has been designed for the detection of alkaline phosphatase (ALP). In the presence of ALP …

An improved fluorogenic substrate for the detection of alkaline phosphatase activity

J Park, Y Kim - Bioorganic & medicinal chemistry letters, 2013 - Elsevier
We designed a new alkaline phosphatase (ALP)-sensitive fluorogenic probe in which a self-
immolative spacer group, p-hydroxybenzyl alcohol, is linked to a profluorogenic compound …

Novel ratiometric fluorescent probe for real-time detection of alkaline phosphatase and its application in living cells

X Huang, X Chen, S Chen, X Zhang, L Wang… - … Acta Part A: Molecular …, 2021 - Elsevier
A novel ratiometric fluorescent probe has been developed through a simple synthetic route
for the detection of alkaline phosphatase (ALP) in aqueous media and for fluorescence …

Ratiometric detection and imaging of endogenous alkaline phosphatase activity by fluorescein-coumarin-based fluorescence probe

J Cao, Q Wu, X Chang, H Chu, H Zhang, X Fang… - … Acta Part A: Molecular …, 2022 - Elsevier
Alkaline phosphatase (ALP) is a type of enzyme that widely exists in various tissues of the
human body; it plays an important role in regulating many cell functions. The development of …

A ratiometric fluorescent probe for alkaline phosphatase with high sensitivity

Y Yangyang, Z Chen, P Rizhao, Z Shiwei… - Chinese Chemical …, 2020 - Elsevier
Alkaline phosphatase (ALP) is one of essential biomarkers in mammalian tissue. Here we
report a ratiometric probe for ALP, which is rationally designed and synthesized by …