Generalised tonic-clonic seizures, generated by abnormal neuronal hyper-activity, cause a
significant and long-lasting increase in the nociceptive threshold. The pedunculopontine …

This study investigated the intrinsic connections of a key‐structure of the endogenous pain
inhibitory system, the pedunculopontine tegmental nucleus (PPTN), in post‐ictal …

The pedunculopontine tegmental nucleus (PPTg) is defined by its collection of cholinergic
neurons surrounding the lateral portion of the superior cerebellar peduncle at the midbrain …

Several studies have suggested the involvement of the hippocampus in the elaboration of
epilepsy. There is evidence that suggests the hippocampus plays an important role in the …

Stimulation-evoked antinociception (SEA) from the anterior pretectal nucleus (APtN)
activates mechanisms that descend to the spinal cord through the dorsolateral funiculus, but …

Electrical stimulation of the anterior pretectal nucleus (APtN) activates two descending pain
inhibitory pathways. One of these pathways relays in the ipsilateral lateral …

The blockade of GABA-mediated Cl− influx with pentylenetetrazol (PTZ) was used in the
present work to induce seizures in Rattus norvegicus. The aim of this work was to study the …

The effects of intraperitoneal (ip) or intrathecal (it) injection of antagonists of acetylcholine,
noradrenaline, serotonin, dopamine, opioids and GABA on stimulation-produced …

The present study showed that the inhibitory effect on the tail-flick reflex (TF) of stimulating
the deep mesencephalic nucleus (DpMe) was very similar to that produced by stimulation of …

We investigated the participation of the nucleus of the tractus solitarius (NTS) in tonic‒clonic
seizures and postictal antinociception control mediated by NMDA receptors, the role of NTS …