Research has long supported the view that the brain is immunologically privileged, in part
because normal, uninfected neurons were not thought to express major histocompatibility …

MHC class II (MHC-II) molecules play a central role in the selection of the T cell repertoire, in
the establishment and regulation of the adaptive immune response, and in autoimmune …

Major histocompatibility complex (MHC) class I genes typically encode polymorphic peptide-
binding chains which are ubiquitously expressed and mediate the recognition of intracellular …

Whether neurons express major histocompatibility complex (MHC) class I genes has not
been firmly established. The techniques of confocal laser microscopy, patch clamp …

MHC‐restricted T cells are thought to contribute to clinical demyelination in MS and other
circumstances. The step‐by‐step mechanisms involved and ways of controlling them are still …

A possible evolutionary history of the MHC is outlined. It is proposed that genes encoding a
peptide-binding structure were transferred to a gene segment encoding an Ig-like domain to …

Virally infected neurons avoid destruction by cytotoxic T lymphocytes (CTLs) by failing to
express major histocompatibility complex (MHC) class I molecules. like neurons in vivo and …

Highly polymorphic major histocompatibility complex (MHC) molecules are at the heart of
adaptive immune responses, playing crucial roles in many kinds of disease and in …

Subsets of rodent neurons are reported to express major histocompatibility complex class I
(MHC-I), but such expression has not been reported in normal adult human neurons. Here …

Abstract MHC-related protein (MR) 1 is an MHC class I-related molecule encoded on
chromosome 1 that is highly conserved among mammals and is more closely related to …