Background: Membrane αKlotho (hereinafter called Klotho) is highly expressed in the kidney
and functions as a coreceptor of FGF receptors (FGFRs) to activate specific fibroblast growth …

FGF23 and Klotho in chronic kidney disease : Current Opinion in Nephrology and
Hypertension FGF23 and Klotho in chronic kidney disease : Current Opinion in Nephrology …

Cardiovascular disease is the leading cause of death in patients with chronic kidney disease
(CKD). As CKD progresses, CKD-specific risk factors, such as disordered mineral …

The klotho gene (KL) was identified first as a putative aging-suppressor gene that extended
life span when overexpressed and accelerated aging-like phenotypes when disrupted in …

Through alternative splicing, Klotho protein exists both as a secreted and a membrane form
whose extracellular domain could be shed from the cell surface by secretases and released …

Fibroblast growth factor (FGF) 23 and Klotho are two factors associated with several
metabolic disorders. Similar to humans, accelerated aging processes characterized by …

Abstract Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates
phosphate and 1, 25-hydroxyvitamin D [1, 25 (OH) 2 D] metabolism. FGF23 binds to FGF …

Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the
Klotho transcript or the extracellular domain of membrane Klotho can be released from …

Abstract Fibroblast growth factor-23 (FGF23) is a bone-derived hormone known to suppress
phosphate reabsorption and vitamin D hormone production in the kidney. Klotho was …

Abnormal mineral metabolism is a hallmark in patients with advanced chronic kidney
disease (CKD). Hyperphosphatemia, and the homeostatic mechanisms controlling …