The structure constituted by a G protein coupled receptor (GPCR) homodimer and a G
protein provides a main functional unit and oligomeric entities can be viewed as multiples of …

Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel
targets for drug development. Accumulating evidence indicates that GPCRs can form …

Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key
modulators of striatal neuronal function. It has been suggested that the psychostimulant …

Adenosine A2A (A2AR) and dopamine D2 (D2R) receptors mediate the antagonism
between adenosinergic and dopaminergic transmission in striatopallidal GABAergic …

Adenosine A2A-dopamine D2 receptor interactions play a very important role in striatal
function. A2A-D2 receptor interactions provide an example of the capabilities of information …

The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell
membrane and allosteric interactions across the A2AR–D2R heteromer represent a target …

In the CNS, an antagonistic interaction has been shown between adenosine A2A and
dopamine D2 receptors (A2 AR s and D2Rs) that may be relevant both in normal and …

The pharmacological significance of the adenosine A 2A receptor (A 2A R)-dopamine D 2
receptor (D 2 R) heteromer is well established and it is being considered as an important …

Several selective antagonists for adenosine A2A receptors (A2AR) are currently under
evaluation in clinical trials (phases I to III) to treat Parkinson's disease, and they will probably …

Emerging evidence shows that G protein-coupled receptors can form homo-and heteromers.
These include adenosine A2A receptor–dopamine D2 receptor heteromers, which are most …