The p16 INK4A tumor suppressor gene participates in establishing and maintaining the
malignant phenotype of a variety of cancer cell lines and primary tumors. Recently it has …

Loss of heterozygosity (LOH) of 9p21, which contains the p16INK4a tumor suppressor gene
locus, is one of the most frequent genetic abnormalities in human neoplasia, including …

Background: The INK4 locus consisting of three genes involved in the regulation of cell
cycle, p16INK4a, p15INK4b, and p14ARF is often disrupted in human neoplasms. Methods …

Background The product of CDKN2A, p16 is an essential regulator of the cell cycle
controlling the entry into the S-phase. Herein, we evaluated CDKN2A promoter methylation …

The molecular mechanisms of hepatocarcinogenesis are poorly understood. Only very
recently has there been a suggestion of familial hepatocellular carcinoma (HCC). We have …

Functional inactivation of the p16INK4a gene has been reported to be involved in the
development of a variety of human malignancies. Recent evidence shows that …

The CDKN2A gene encodes a cyclin-dependent kinase inhibitor, p16, which promotes cell
cycle arrest. Methylation of the promoter region of the gene transcriptionally inactivates the …

The inactivation of the cyclin-dependent kinase inhibitor p16INK4A gene by
hypermethylation is observed in numerous types of cancer. New findings indicate that DNA …

Stable epigenetic silencing of p16 INK4a is a common event in hepatocellular carcinoma
(HCC) cells, which is associated with abnormal cell proliferation and liberation from cell …

The INK4a-ARF locus plays a central role in the development of pancreatic tumors as
evidenced by the fact that up to 98% of pancreatic tumor specimens harbored genetic …