Extensive Methylation Is Associated with β-Catenin Mutations in Hepatocellular Carcinoma: Evidence for Two Distinct Pathways of Human Hepatocarcinogenesis
N Nishida, T Nishimura, T Nagasaka, I Ikai, G Ajay… - Cancer research, 2007 - AACR
Hepatocellular carcinoma (HCC) with p53 mutations is usually characterized by extensive
chromosomal instability (CIN), whereas those with β-catenin mutations have relatively less …
chromosomal instability (CIN), whereas those with β-catenin mutations have relatively less …
Increase in the frequency of p16 INK4 gene inactivation by hypermethylation in lung cancer during the process of metastasis and its relation to the status of p53
M Seike, A Gemma, Y Hosoya, S Hemmi… - Clinical cancer …, 2000 - AACR
The p16 INK4 gene, which is a tumor suppressor gene, is frequently altered in lung cancers.
Hypermethylation of the promoter region of the p16 INK4 gene seems to be the major …
Hypermethylation of the promoter region of the p16 INK4 gene seems to be the major …
p16 INK4A Alterations are accompanied by aberrant protein immunostaining in endometrial carcinomas
A Semczuk, C Boltze, B Marzec, A Szczygielska… - Journal of cancer …, 2003 - Springer
Purpose To date, the significance of p16 INK4A tumor suppressor gene inactivation in
sporadic endometrial cancer (EC) has only rarely been described. In this study, we …
sporadic endometrial cancer (EC) has only rarely been described. In this study, we …
Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous‐cell‐carcinoma cell lines
H Tanaka, Y Shimada, M Imamura… - … journal of cancer, 1997 - Wiley Online Library
To determine the role and mode of inactivation of the p16 and p15 genes in human
esophageal tumors, we examined alterations and expression of the α and β forms of the p16 …
esophageal tumors, we examined alterations and expression of the α and β forms of the p16 …
[HTML][HTML] Possible down regulation of the p16 gene promoter in individuals with hepatocellular carcinoma
OB Shiraz, H Galehdari, M Yavarian… - Hepatitis …, 2011 - ncbi.nlm.nih.gov
Background The p16 tumor suppressor gene is an important negative regulator of the cell
cycle. Inactivation of p16, especially via promoter hypermethylation, has been found in …
cycle. Inactivation of p16, especially via promoter hypermethylation, has been found in …
Gene Deletion Chemoselectivity: Codeletion of the Genes for p16INK4, Methylthioadenosine Phosphorylase, and the α- and β-Interferons in Human Pancreatic Cell …
ZH Chen, H Zhang, TM Savarese - Cancer research, 1996 - AACR
Pancreatic carcinoma cells lines are known to have a high incidence of homozygous
deletion of the candidate tumor suppressor gene p16 (MTS1/CDKN2), which resides in the …
deletion of the candidate tumor suppressor gene p16 (MTS1/CDKN2), which resides in the …
The Role of DNA Methylation in Expression of the p19/p16 Locus in Human Bladder Cancer Cell Lines
ML Gonzalgo, T Hayashida, CM Bender, MM Pao… - Cancer research, 1998 - AACR
Methylation of CpG sites in the control regions of tumor suppressor genes may be an
important mechanisms for their heritable, yet reversible, transcriptional inactivation. These …
important mechanisms for their heritable, yet reversible, transcriptional inactivation. These …
Correlation between methylation status of the p16/CDKN2 gene and the expression of p16 and Rb proteins in primary non‐small cell lung cancers
K Kashiwabara, T Oyama, T Sano… - … journal of cancer, 1998 - Wiley Online Library
In order to clarify the frequency of p16 gene inactivation and its relationship with Rb
expression, immunohistochemical analysis of p16 and Rb proteins was carried out on 82 …
expression, immunohistochemical analysis of p16 and Rb proteins was carried out on 82 …
Association of K-ras mutations with p16 methylation in human colon cancer
RJ Guan, Y Fu, PR Holt, AB Pardee - Gastroenterology, 1999 - Elsevier
Background & Aims: K-ras mutations are early genetic changes in colon cancer. p16, a
tumor-suppressor gene, is inactivated in neoplasms by mutation, deletion, or methylation …
tumor-suppressor gene, is inactivated in neoplasms by mutation, deletion, or methylation …
Inactivation of the p16 gene in human pituitary nonfunctioning tumors by hypermethylation is more common in null cell adenomas
KH Ruebel, L Jin, S Zhang, BW Scheithauer… - Endocrine …, 2001 - Springer
Recent studies have shown that methylation of the CpG island within the
p16/CDKN2A/MTS1 (p16) gene is associated with loss of expression of p16 protein in …
p16/CDKN2A/MTS1 (p16) gene is associated with loss of expression of p16 protein in …