Abstract Background and Aim: Genetic silencing by promoter methylation has attracted
attention in the carcinogenesis of colorectal cancer. Methylation of the p16INK4a gene has …

Abstract Background: Methylation of the CpG islands in the p16 gene promoter region is an
important transcription repression mechanism that has been identified as an alternative …

The inactivation of the cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor p16INK4A may
be caused by gene deletion, mutation or promoter hypermethylation. We have previously …

The p16INK4A gene mapped on band p21 of chromosome 9 can be inactivated via multiple
mechanisms including homozygous deletion, point mutation and promoter hypermethylation …

Background The p16INK4 (MTS1/CDNK2A) gene, located on chromosome 9p21, is an
inhibitor of cyclin-dependent kinase 4. Various data have shown that it is frequently …

Abstract The p16INK4A (CDKN2A/MTS1) putative tumor suppressor gene encodes a cyclin
dependent kinase inhibitor which plays an important role in the regulation of the G1/S phase …

Abstract The CDKN2A (p16 INK4a) cell cycle-inhibitory gene has been associated with
development of familial melanoma. Additionally, recent studies indicate that p16 alterations …

The recently identified cyclin-dependent kinase inhibitor p15INK4B is localized to a region
on chromosome 9p21 frequently deleted in human tumors. Previous evidence has pointed …

The p16INK4A/CDKN2A tumor suppressor gene is known to be inactivated in up to 98% of
human pancreatic cancer specimens and represents a potential target for novel therapeutic …

Abnormality of the p16 expression is involved in the pathogenesis of hepatocellular
carcinoma (HCC), and hypermethylation of p16 gene is known as a major p16 inactivation …