TAK1 targeting by glucocorticoids determines JNK and IκB regulation in Toll-like receptor–stimulated macrophages
S Bhattacharyya, CK Ratajczak, SK Vogt… - Blood, The Journal …, 2010 - ashpublications.org
Glucocorticoids potently attenuate the production of inflammatory mediators by
macrophages, a primary effector of innate immunity. Activation of different macrophage Toll …
macrophages, a primary effector of innate immunity. Activation of different macrophage Toll …
Cell type-specific function of TAK1 in innate immune signaling
AA Ajibade, HY Wang, RF Wang - Trends in immunology, 2013 - cell.com
Transforming growth factor β-activated kinase 1 (TAK1 or MAP3K7) is a key signaling
component of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …
component of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) …
A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease
J Zhou, R Wu, AA High, CA Slaughter… - Proceedings of the …, 2011 - National Acad Sciences
Toll-like receptors (TLRs) are expressed on innate immune cells and trigger inflammation
upon detection of pathogens and host tissue injury. TLR-mediated proinflammatory …
upon detection of pathogens and host tissue injury. TLR-mediated proinflammatory …
TAK1, more than just innate immunity
Transforming growth factor β‐activated kinase 1 (TAK1) is a key regulator of the innate
immunity and the proinflammatory signaling pathway. In response to interleukin‐1, tumor …
immunity and the proinflammatory signaling pathway. In response to interleukin‐1, tumor …
Myeloid TAKL acts as a negative regulator of the LPS response and mediates resistance to endotoxemia
C Eftychi, N Karagianni, M Alexiou, M Apostolaki… - PloS one, 2012 - journals.plos.org
TGFβ-activated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase
kinase (MAP3K) family, is considered a key intermediate in a multitude of innate immune …
kinase (MAP3K) family, is considered a key intermediate in a multitude of innate immune …
Macrophage glucocorticoid receptors regulate Toll-like receptor 4–mediated inflammatory responses by selective inhibition of p38 MAP kinase
S Bhattacharyya, DE Brown, JA Brewer, SK Vogt… - Blood, 2007 - ashpublications.org
To explore the role of glucocorticoids in regulation of kinase pathways during innate immune
responses, we generated mice with conditional deletion of glucocorticoid receptor (GR) in …
responses, we generated mice with conditional deletion of glucocorticoid receptor (GR) in …
[HTML][HTML] TAK1 mediates an activation signal from toll-like receptor (s) to nuclear factor-κB in lipopolysaccharide-stimulated macrophages
T Irie, T Muta, K Takeshige - FEBS letters, 2000 - Elsevier
Stimulation of monocytes/macrophages with lipopolysaccharide (LPS) results in activation of
nuclear factor-κB (NF-κB), which plays crucial roles in regulating expression of many genes …
nuclear factor-κB (NF-κB), which plays crucial roles in regulating expression of many genes …
Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor–induced STAT1 activation
S Bhattacharyya, Y Zhao, TWH Kay… - Proceedings of the …, 2011 - National Acad Sciences
Endogenous and pharmacologic glucocorticoids (GCs) limit inflammatory cascades initiated
by Toll-like receptor (TLR) activation. A long-standing clinical observation has been the …
by Toll-like receptor (TLR) activation. A long-standing clinical observation has been the …
Cutting edge: TAK1 safeguards macrophages against proinflammatory cell death
H Sanjo, J Nakayama, T Yoshizawa… - The Journal of …, 2019 - journals.aai.org
Abstract TGF-β–activated kinase 1 (TAK1) is known to play vital roles for innate and adaptive
immunity; however, little is known about its potential role in limiting biological responses …
immunity; however, little is known about its potential role in limiting biological responses …
Toll-like receptor 2 release by macrophages: an anti-inflammatory program induced by glucocorticoids and lipopolysaccharide
J Hoppstädter, A Dembek, R Linnenberger… - Frontiers in …, 2019 - frontiersin.org
Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory
diseases, and endogenous GCs play a key role in immune regulation. Toll-like receptors …
diseases, and endogenous GCs play a key role in immune regulation. Toll-like receptors …