We evaluated whether aliskiren, valsartan, or a combination of both was protective following
myocardial infarction (MI) through effects on matrix metalloproteinase (MMP)-9. C57BL/6J …

Matrix metalloproteinases (MMPs) and the tissue inhibitors of MMPs (TIMPs) have been
recognized to play a pivotal role in matrix remodeling following myocardial infarction (MI) …

Left ventricular (LV) remodeling is the main reason for the development of progressive
cardiac dysfunction after myocardial infarction (MI). This study investigated whether …

This study compares the effect of two different strategies to inhibit the renin–angiotensin
system in the setting of acute myocardial infarction (MI). Male Wistar rats were treated with …

Since the early 1990's, angiotensin converting enzyme (ACE) inhibitors have been used
clinically to improve survival and reduce adverse left ventricular (LV) remodeling following …

Rationale: Matrix metalloproteinase (MMP)-28 regulates the inflammatory and extracellular
matrix responses in cardiac aging, but the roles of MMP-28 after myocardial infarction (MI) …

Extracellular matrix (ECM) remodeling and increased matrix metalloproteinase (MMP)
expression and activity have been observed to be relevant in the development of heart …

Aims The plasma level of interleukin-6 (IL-6) has been reported to be associated with left
ventricular (LV) remodelling after myocardial infarction (MI). The present study was designed …

The efficacy of aliskiren, a direct renin inhibitor, in ventricular remodeling after myocardial
infarction (MI) compared with conventional renin–angiotensin system (RAS) inhibitors …

Favorable effects of angiotensin II type 1 receptor blockers on patients with ischemic or
idiopathic dilated cardiomyopathy (DCM) have already been suggested by several human …