[PDF][PDF] Prospects for admixture mapping of complex traits

PM McKeigue - The American Journal of Human Genetics, 2005 - cell.com
Admixture mapping extends to human populations the principles that underlie linkage
analysis of an experimental cross. For detecting genes that contribute to ethnic variation in …

[PDF][PDF] Statistical tests for admixture mapping with case-control and cases-only data

G Montana, JK Pritchard - The American Journal of Human Genetics, 2004 - cell.com
Admixture mapping is a promising new tool for discovering genes that contribute to complex
traits. This mapping approach uses samples from recently admixed populations to detect …

Admixture mapping comes of age

CA Winkler, GW Nelson… - Annual review of genomics …, 2010 - annualreviews.org
Admixture mapping is based on the hypothesis that differences in disease rates between
populations are due in part to frequency differences in disease-causing genetic variants. In …

Overview of admixture mapping

D Shriner - Current protocols in human genetics, 2017 - Wiley Online Library
Admixture mapping is a powerful method of gene mapping for diseases or traits that show
differential risk by ancestry. Admixture mapping has been applied most often to Americans …

Measuring and using admixture to study the genetics of complex diseases

I Halder, MD Shriver - Human genomics, 2003 - Springer
Admixture is an important evolutionary force that can and should be used in efforts to apply
genomic data and technology to the study of complex disease genetics. Admixture linkage …

[PDF][PDF] A genomewide admixture mapping panel for Hispanic/Latino populations

X Mao, AW Bigham, R Mei, G Gutierrez… - The American Journal of …, 2007 - cell.com
Admixture mapping (AM) is a promising method for the identification of genetic risk factors
for complex traits and diseases showing prevalence differences among populations …

[PDF][PDF] Design and analysis of admixture mapping studies

CJ Hoggart, MD Shriver, RA Kittles, DG Clayton… - The American Journal of …, 2004 - cell.com
Admixture between populations originating on different continents can be exploited to detect
disease susceptibility loci at which risk alleles are distributed differentially between these …

[PDF][PDF] A high-density admixture map for disease gene discovery in African Americans

MW Smith, N Patterson, JA Lautenberger… - The American Journal of …, 2004 - cell.com
Admixture mapping (also known as" mapping by admixture linkage disequilibrium," or
MALD) provides a way of localizing genes that cause disease, in admixed ethnic groups …

Mapping by admixture linkage disequilibrium: advances, limitations and guidelines

MW Smith, SJ O'Brien - Nature Reviews Genetics, 2005 - nature.com
Mapping by admixture linkage disequilibrium (MALD) is a theoretically powerful, although
unproven, approach to mapping genetic variants that are involved in human disease. MALD …

Local and global ancestry inference and applications to genetic association analysis for admixed populations

TA Thornton, JL Bermejo - Genetic epidemiology, 2014 - Wiley Online Library
Genetic association studies in recently admixed populations offer exciting opportunities to
identify novel variants underlying phenotypic diversity. At the same time, genetic …