The cyclin‐dependent kinase inhibitor (CDKi) drugs such as R‐roscovitine have emerged as
potential anti‐inflammatory, pharmacological agents that can influence the resolution of …

Successful resolution of inflammation requires inflammatory cells such as neutrophils to
undergo apoptosis prior to non‐inflammatory phagocytosis by professional phagocytes …

Apoptosis is essential for clearance of potentially injurious inflammatory cells and
subsequent efficient resolution of inflammation. Here we report that human neutrophils …

Neutrophils are the most abundant leukocyte and play a central role in the immune defense
against rapidly dividing bacteria. However, they are also the shortest lived cell in the blood …

Terminally differentiated neutrophils are short-lived but the key effector cells of the innate
immune response, and have a prominent role in the pathogenesis and propagation of many …

BACKGROUND AND PURPOSE Roscovitine, a cyclin‐dependent kinase (CDK) inhibitor
that induces tumour cell death, is under evaluation as an anti‐cancer drug. By triggering …

Chronic inflammation is an underlying cause in a number of diseases. Cyclin-dependent
kinase 8 (CDK8) has been implicated as an inflammatory mediator, indicating its potential as …

Apoptosis of granulocytes and the subsequent clearance of apoptotic cells are important
processes for the successful resolution of inflammation. Signalling pathways, including …

Inflammation is a necessary dynamic tissue response to injury or infection and it's resolution
is essential to return tissue homeostasis and function. Defective or dysregulated …

Cell cycle re-entry of quiescent T lymphocytes regulated by cdk2 is required for antigen-
specific clonal expansion and generation of productive T cell responses. Recently, we …