Iron is a trace element of considerable interest to both chemistry and biology. In a biological
context its chemistry is vital to the roles it performs. However, that same chemistry can …

Iron (Fe) is an essential element for many metabolic processes, serving as a cofactor for
heme and nonheme proteins. Cellular iron deficiency arrests cell growth and leads to cell …

Brain iron deposits have been reported consistently in imaging and histologic examinations
of patients with neurodegenerative disorders. While the origins of this finding have not been …

The brain shares with other organs the need for a constant and readily available supply of
iron and has a similar array of proteins available to it for iron transport, storage, and …

Accumulation of iron (Fe) is often detected in the brains of people suffering from
neurodegenerative diseases. High Fe concentrations have been consistently observed in …

Iron is the most abundant transition metal within the brain, and is vital for a number of
cellular processes including neurotransmitter synthesis, myelination of neurons, and …

Brain iron is tightly regulated by a multitude of proteins to ensure homeostasis. Iron
dyshomeostasis has become a molecular signature associated with aging which is …

The accumulation of transition metals (eg, copper, zinc, and iron) and the dysregulation of
their metabolism are a hallmark in the pathogenesis of several neurodegenerative diseases …

Enormous advances have been made in the last decade in understanding iron metabolism
and iron homeostasis at both the cellular and the systemic level. This includes the …

Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …