By changing the molar ratio of hydrophilic and hydrophobic segments, a series of novel
amphiphilic graft polyphosphazenes (PEG/EtTrp-PPPs) was synthesized via thermal ring …

Many macromolecular therapeutics such as peptides, proteins, antisense
oligodeoxynucleotides (ASODN), and short interfering RNA (siRNA) are active only in the …

Targeting drugs at mitochondria may provide an effective means of inducing cell death for
cancer therapy. Here, we introduce a conjugate of a dual-ligand-modified N-(2 …

There is a recognized need to create well-defined polymer probes for in vivo and clinical
positron emission tomography (PET) imaging to guide the development of new generation …

Over the past few decades, numerous polymer drug carrier systems are designed and
synthesized, and their properties are evaluated. Many of these systems are based on water …

We report on the preparation of novel functional multilayered polymeric nanocarriers for
targeted cell delivery from a binary mixture of amphiphilic poly (ethylene oxide)-poly (ε …

The development of macromolecules as drugs and drug carriers requires knowledge of their
fate in cells. To this end, we studied the internalization and subcellular fate of N-(2 …

Polyethylene glycol or phosphorylcholine is often introduced into polycationic non-viral
vectors to inhibit the non-specific protein adsorption. However the ability of vectors to …

Copolymers of N-(2-hydroxypropyl) methacrylamide (HPMA) are prototypic and well-
characterized polymeric drug carriers that are being broadly implemented in the delivery of …

Mitochondria are important targets for the intracellular delivery of drugs and DNA. For
mitochondria-targeted delivery, a mitochondriotropic molecule, triphenylphosphonium …