A new strategy for the synthesis of biodegradable high molecular weight N-(2-
hydroxypropyl) methacrylamide (HPMA)-based polymeric carriers has been designed. An …

Achieving intracellular delivery of protein therapeutics within cells remains a significant
challenge. Although custom formulations are available for some protein therapeutics, the …

Lipid bilayers in biomembranes consist of diverse phospholipids, including phosphatidic
acid (PA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), and …

pH-responsive drug carriers derived from polymers containing weak base groups have been
shown to improve the antitumor effect of chemotherapeutics. The common interpretation is …

The design, synthesis and properties of N-(2-hydroxypropyl) methacrylamide (HPMA)
copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics …

We report the synthesis and characterization of an amphiphilic polymer comprising a
hydrophobic palmitoyl (Pal) group and a zwitterionic poly (2-methacryloyloxyethyl …

Polymer-based drug delivery systems may significantly improve cancer therapy. We
developed amphiphilic poly (ε-caprolactone)-graft-(poly-N-(2-hydroxypropyl) …

The facile synthesis of biocompatible and nontoxic gene delivery vectors has been the focus
of research in recent years due to the high potential in treating genetic diseases. 2 …

The water-soluble, biocompatible polymer poly (2-methacryloyloxyethyl phosphorylcholine)(
PMPC) was evaluated for protein conjugation. PMPC is a zwitterionic polymer that is able to …

We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl)
methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the …