A series of novel, fluorescent ligands designed to bind with high affinity and specificity to the
asialoglycoprotein receptor (ASGP-R) has been synthesized and tested on human liver …

A compact and stable bicyclic bridged ketal was developed as a ligand for the
asialoglycoprotein receptor (ASGPR). This compound showed excellent ligand efficiency …

A series of novel aryl-substituted triazolyl d-galactosamine derivatives was synthesized as
ligands for the carbohydrate recognition domain of the major subunit H1 (H1-CRD) of the …

The asialoglycoprotein receptor (ASGPR) is a high-capacity galactose-binding receptor
expressed on hepatocytes that binds its native substrates with low affinity. More potent …

In order to develop the non-viral Bioplex vector system for targeted delivery of genes to
hepatocytes, we have evaluated the structure-function relationship for a number of synthetic …

Targeted delivery of therapeutic agents to hepatocytes is a particularly attractive strategy for
the treatment of hepatocellular carcinoma and other liver diseases. The asialoglycoprotein …

The asialoglycoprotein receptor (ASGPr) on hepatocytes plays a role in the clearance of
desialylated proteins from the serum. Although its sugar preference (N-acetylgalactosamine …

A series of peptidylglycoside derivatives, including the tris (GalNAc‐aminohexyl) glycoside
of tyrosyl (glutamyl)‐glutamate (1) which is known to have sub‐nanomolar affinity for the …

In vivogene therapy shows promise as a treatment for both genetic and acquired disorders.
The hepatic asialoglycoprotein receptor (ASGPr) binds asialoorosomucoid—polylysine …

Structurally well defined di-and tri-antennary lysine-based galactose-and N-
acetylgalactosamine-containing ligands for the hepatic asialoglycoprotein receptor (ASGP …