Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers
PURPOSE: Epidermal growth factor receptor (EGFR) mutations have been found in the
majority of gefitinib-responsive non-small cell lung cancer (NSCLC) patients from …
majority of gefitinib-responsive non-small cell lung cancer (NSCLC) patients from …
Ethnic differences in response to epidermal growth factor receptor tyrosine kinase inhibitors
E Calvo, J Baselga - Journal of Clinical Oncology, 2006 - ascopubs.org
The identification of somatic mutations in the tyrosine kinase domain of the epidermal growth
factor receptor (EGFR) in non–small-cell lung cancer (NSCLC) and their correlation with …
factor receptor (EGFR) in non–small-cell lung cancer (NSCLC) and their correlation with …
Establishment of a human non‐small cell lung cancer cell line resistant to gefitinib
F Koizumi, T Shimoyama, F Taguchi… - … journal of cancer, 2005 - Wiley Online Library
The epidermal growth factor receptor (EGFR) tyrosine‐kinase inhibitor gefitinib (Iressa®,
ZD1839) has shown promising activity preclinically and clinically. Because comparative …
ZD1839) has shown promising activity preclinically and clinically. Because comparative …
EGFR mutations and lung cancer
G da Cunha Santos, FA Shepherd… - Annual Review of …, 2011 - annualreviews.org
Epidermal growth factor receptor (EGFR) is a transmembrane protein with cytoplasmic
kinase activity that transduces important growth factor signaling from the extracellular milieu …
kinase activity that transduces important growth factor signaling from the extracellular milieu …
Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor
(EGFR) gene are present in lung adenocarcinomas that respond to the EGFR inhibitors …
(EGFR) gene are present in lung adenocarcinomas that respond to the EGFR inhibitors …
Epidermal growth factor receptor activation: how exon 19 and 21 mutations changed our understanding of the pathway
The discovery of epidermal growth factor receptor (EGFR) mutations in never-smokers has
been the most relevant finding ever in non–small cell lung cancer. When patients whose …
been the most relevant finding ever in non–small cell lung cancer. When patients whose …
[HTML][HTML] Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update
G Bethune, D Bethune, N Ridgway… - Journal of thoracic …, 2010 - ncbi.nlm.nih.gov
Epidermal growth factor receptor is a trans-membrane glycoprotein with an extracellular
epidermal growth factor binding domain and an intracellular tyrosine kinase domain that …
epidermal growth factor binding domain and an intracellular tyrosine kinase domain that …
[引用][C] Absence of EGFR mutation in the kinase domain in common human cancers besides non‐small cell lung cancer
JW Lee, YH Soung, SY Kim, WS Park… - … Journal of Cancer, 2005 - Wiley Online Library
The epidermal growth factor receptor (EGFR), a receptor protein tyrosine kinase, contributes
to a number of processes in tumor survival and growth activity, thus making it a promising …
to a number of processes in tumor survival and growth activity, thus making it a promising …
[HTML][HTML] The EGFR mutation and its correlation with response of gefitinib in previously treated Chinese patients with advanced non-small-cell lung cancer
XT Zhang, LY Li, XL Mu, QC Cui, XY Chang, W Song… - Annals of oncology, 2005 - Elsevier
Background: The aim of the study was to evaluate the efficacy of gefitinib and the epidermal
growth factor receptor (EGFR) mutation to gefitinib response in a series of Chinese patients …
growth factor receptor (EGFR) mutation to gefitinib response in a series of Chinese patients …
EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer
SH Choi, JM Mendrola, MA Lemmon - Oncogene, 2007 - nature.com
Several somatic mutations within the tyrosine kinase domain of epidermal growth factor
receptor (EGFR) have been identified that predict clinical response of non-small-cell lung …
receptor (EGFR) have been identified that predict clinical response of non-small-cell lung …