Chronic obstructive pulmonary disease in the older adult: what defines abnormal lung function?

DM Mannino, AS Buist, WM Vollmer - Thorax, 2007 - thorax.bmj.com
Background: The Global Initiative on Obstructive Lung Disease stages for chronic
obstructive pulmonary disease (COPD) uses a fixed ratio of the post-bronchodilator forced …

[HTML][HTML] Chronic obstructive pulmonary disease in older persons: a comparison of two spirometric definitions

CAV Fragoso, J Concato, G McAvay, PH Van Ness… - Respiratory …, 2010 - Elsevier
BACKGROUND: Among older persons, we previously endorsed a two-step spirometric
definition of chronic obstructive pulmonary disease (COPD) that requires a ratio of forced …

Rate of normal lung function decline in ageing adults: a systematic review of prospective cohort studies

ET Thomas, M Guppy, SE Straus, KJL Bell… - BMJ open, 2019 - bmjopen.bmj.com
Objective To conduct a systematic review investigating the normal age-related changes in
lung function in adults without known lung disease. Design Systematic review. Data sources …

Risk of over-diagnosis of COPD in asymptomatic elderly never-smokers

JA Hardie, AS Buist, WM Vollmer… - European …, 2002 - Eur Respiratory Soc
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has defined stage 1
chronic obstructive pulmonary disease (COPD) as forced expiratory volume in one …

[HTML][HTML] Lung function testing in the elderly—can we still use FEV1/FVC< 70% as a criterion of COPD?

A Medbø, H Melbye - Respiratory medicine, 2007 - Elsevier
BACKGROUND: Chronic obstructive pulmonary disease (COPD) can be diagnosed when
the FEV1/FVC ratio is below 70%, according to global initiative for chronic obstructive lung …

[HTML][HTML] GOLD or lower limit of normal definition? A comparison with expert-based diagnosis of chronic obstructive pulmonary disease in a prospective cohort-study

G Güder, S Brenner, CE Angermann, G Ertl, M Held… - Respiratory …, 2012 - Springer
Abstract Background The Global initiative for chronic Obstructive Lung Disease (GOLD)
defines COPD as a fixed post-bronchodilator ratio of forced expiratory volume in 1 second …

Lung function decline and outcomes in an elderly population

DM Mannino, KJ Davis - Thorax, 2006 - thorax.bmj.com
Objective: To determine the risk factors for and outcomes associated with the rapid decline
in lung function in a cohort of elderly US adults. Methods: Data from 4923 adult participants …

[HTML][HTML] Comorbidities and mortality risk in adults younger than 50 years of age with chronic obstructive pulmonary disease

MJ Divo, JM Marin, C Casanova, C Cabrera Lopez… - Respiratory …, 2022 - Springer
Rationale and objective Patients with chronic obstructive pulmonary disease (COPD),
usually diagnosed after the 6th decade, frequently suffer from comorbidities. Whether COPD …

Interpreting lung function data using 80% predicted and fixed thresholds identifies patients at increased risk of mortality

DM Mannino, E Diaz-Guzman - Chest, 2012 - Elsevier
Background The GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages for
COPD use a fixed ratio of the postbronchodilator FEV 1/FVC ratio of 0.70 as a threshold to …

The Ratio of FEV1 to FVC as a Basis for Establishing Chronic Obstructive Pulmonary Disease

CA Vaz Fragoso, J Concato, G McAvay… - American journal of …, 2010 - atsjournals.org
Rationale: The lambda-mu-sigma (LMS) method is a novel approach that defines the lower
limit of normal (LLN) for the ratio of FEV1/FVC as the fifth percentile of the distribution of Z …